Document Detail

Glucocorticoids and insulin both modulate caloric intake through actions on the brain.
MedLine Citation:
PMID:  17556388     Owner:  NLM     Status:  MEDLINE    
Glucocorticoids act primarily in a feed-forward fashion on brain to activate CNS pathways that implement wanting appropriate to physiological needs. Thus, depending on the available conditions, elevated glucocorticoids may augment the behavioural want to run, fight or feed. Although glucocorticoids stimulate intake of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in fat, acting through hepatic branch afferents of the vagus nerve. Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity.
Mary F Dallman; James P Warne; Michelle T Foster; Norman C Pecoraro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-06-07
Journal Detail:
Title:  The Journal of physiology     Volume:  583     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-20     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Department of Physiology, University of California San Francisco, San Francisco, CA 94143-0444, USA.
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MeSH Terms
Brain / metabolism*,  physiopathology
Dietary Fats / metabolism
Dietary Sucrose / metabolism
Energy Intake*
Feedback, Physiological
Feeding Behavior*
Glucocorticoids / metabolism*
Hypothalamo-Hypophyseal System / metabolism,  physiopathology
Insulin / metabolism*
Liver / innervation,  metabolism
Obesity / metabolism*,  physiopathology
Pituitary-Adrenal System / metabolism,  physiopathology
Vagus Nerve / physiopathology
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Sucrose; 0/Glucocorticoids; 0/Insulin; 61789-99-9/lard
Comment In:
J Physiol. 2007 Sep 1;583(Pt 2):423   [PMID:  17766646 ]

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