| Glucocorticoids and insulin both modulate caloric intake through actions on the brain. | |
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MedLine Citation:
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PMID: 17556388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoids act primarily in a feed-forward fashion on brain to activate CNS pathways that implement wanting appropriate to physiological needs. Thus, depending on the available conditions, elevated glucocorticoids may augment the behavioural want to run, fight or feed. Although glucocorticoids stimulate intake of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in fat, acting through hepatic branch afferents of the vagus nerve. Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity. |
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Authors:
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Mary F Dallman; James P Warne; Michelle T Foster; Norman C Pecoraro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-06-07 |
Journal Detail:
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Title: The Journal of physiology Volume: 583 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-03 Completed Date: 2007-11-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of California San Francisco, San Francisco, CA 94143-0444, USA. mary.dallman@ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Brain / metabolism*, physiopathology Dietary Fats / metabolism Dietary Sucrose / metabolism Energy Intake* Feedback, Physiological Feeding Behavior* Glucocorticoids / metabolism* Humans Hypothalamo-Hypophyseal System / metabolism, physiopathology Insulin / metabolism* Liver / innervation, metabolism Obesity / metabolism*, physiopathology Pituitary-Adrenal System / metabolism, physiopathology Vagus Nerve / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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DA16994/DA/NIDA NIH HHS; DK28172/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Sucrose; 0/Glucocorticoids; 11061-68-0/Insulin; 61789-99-9/lard |
| Comments/Corrections | |
Comment In:
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J Physiol. 2007 Sep 1;583(Pt 2):423
[PMID:
17766646
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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