Document Detail


Glucocorticoids, inflammation and the perinatal lung.
MedLine Citation:
PMID:  11972434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many women delivering preterm infants at less than 30 weeks gestation have subclinical chorioamnionitis. Based on current guidelines, maternal glucocorticoid treatment is given to induce lung maturation. Fetal exposure to proinflammation can cause acute and chronic injury, but inflammation also can induce fetal lung maturation. Both antenatal glucocorticoids and inflammation modulate lung development, by inducing the surfactant system, inducing structural maturation, and inhibiting alveolarization. The opportunities for the future are to develop new safer strategies to mature the preterm foetus, and the risks are potential adverse interactions of repetitive glucocorticoid exposures and unrecognized fetal exposure to inflammation.
Authors:
A H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  6     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  331-42     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Affiliation:
Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. jobeaØ@chmcc.org
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MeSH Terms
Descriptor/Qualifier:
Female
Fetal Organ Maturity / drug effects
Glucocorticoids / pharmacology*
Humans
Infant, Newborn
Infant, Premature
Inflammation / physiopathology*
Lung / drug effects*,  embryology*
Pregnancy
Prenatal Care
Respiratory Distress Syndrome, Newborn / prevention & control
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS; HL-65397/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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