Document Detail

Glucocorticoids differentially increase nerve growth factor and basic fibroblast growth factor expression in the rat brain.
MedLine Citation:
PMID:  8604057     Owner:  NLM     Status:  MEDLINE    
Adrenocorticotropin hormone (ACTH) and adrenal steroids may influence trophic processes operative in neuronal plasticity. Because nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) participate in neuronal trophism, we have investigated whether adrenal steroids induce the expression of these two trophic factors in the rat brain. The systemic administration of dexamethasone (DEX) elicited a rapid (within 3 hr) and sustained accumulation of bFGF and NGF mRNA in the cerebral cortex and hippocampus. Regional studies showed that DEX increases bFGF but not NGF mRNA in the cerebellum, striatum, and hypothalamus. In situ hybridization studies revealed that DEX increases NGF mRNA in superficial layers of the cerebral cortex and in the dentate gyrus of the hippocampus, and bFGF mRNA throughout the brain, suggesting that DEX induces NGF mRNA in neurons and bFGF in glial cells. ACTH administered systemically elicited a temporal and regional induction in NGF and bFGF mRNA similar to that obtained with DEX. Increases in NGF and bFGF mRNAs were also observed after administration of corticosterone and, albeit to a lesser extent, aldosterone, suggesting that the pituitary-adrenocortical axis plays an important role in the regulation of NGF and bFGF expression in the brain. Our data suggest that NGF and bFGF represent a link by which the adrenal cortical system can exert trophic action on the CNS.
I Mocchetti; G Spiga; V Y Hayes; P J Isackson; A Colangelo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  16     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-05-15     Completed Date:  1996-05-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2141-8     Citation Subset:  IM    
Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, USA.
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology
Aldosterone / pharmacology
Brain Chemistry*
Cerebral Cortex / chemistry,  physiology
Corticosterone / pharmacology
Dexamethasone / pharmacology
Dose-Response Relationship, Drug
Fibroblast Growth Factor 2 / drug effects,  genetics*
Gene Expression / drug effects
Glucocorticoids / pharmacology*
Hippocampus / chemistry,  physiology
Nerve Growth Factors / drug effects,  genetics*
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Time Factors
Grant Support
Reg. No./Substance:
0/Glucocorticoids; 0/Nerve Growth Factors; 0/RNA, Messenger; 103107-01-3/Fibroblast Growth Factor 2; 50-02-2/Dexamethasone; 50-22-6/Corticosterone; 52-39-1/Aldosterone; 9002-60-2/Adrenocorticotropic Hormone

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