| Glucocorticoids differentially increase nerve growth factor and basic fibroblast growth factor expression in the rat brain. | |
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MedLine Citation:
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PMID: 8604057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenocorticotropin hormone (ACTH) and adrenal steroids may influence trophic processes operative in neuronal plasticity. Because nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) participate in neuronal trophism, we have investigated whether adrenal steroids induce the expression of these two trophic factors in the rat brain. The systemic administration of dexamethasone (DEX) elicited a rapid (within 3 hr) and sustained accumulation of bFGF and NGF mRNA in the cerebral cortex and hippocampus. Regional studies showed that DEX increases bFGF but not NGF mRNA in the cerebellum, striatum, and hypothalamus. In situ hybridization studies revealed that DEX increases NGF mRNA in superficial layers of the cerebral cortex and in the dentate gyrus of the hippocampus, and bFGF mRNA throughout the brain, suggesting that DEX induces NGF mRNA in neurons and bFGF in glial cells. ACTH administered systemically elicited a temporal and regional induction in NGF and bFGF mRNA similar to that obtained with DEX. Increases in NGF and bFGF mRNAs were also observed after administration of corticosterone and, albeit to a lesser extent, aldosterone, suggesting that the pituitary-adrenocortical axis plays an important role in the regulation of NGF and bFGF expression in the brain. Our data suggest that NGF and bFGF represent a link by which the adrenal cortical system can exert trophic action on the CNS. |
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Authors:
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I Mocchetti; G Spiga; V Y Hayes; P J Isackson; A Colangelo |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 16 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-15 Completed Date: 1996-05-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2141-8 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology Aldosterone / pharmacology Animals Brain Chemistry* Cerebral Cortex / chemistry, physiology Corticosterone / pharmacology Dexamethasone / pharmacology Dose-Response Relationship, Drug Fibroblast Growth Factor 2 / drug effects, genetics* Gene Expression / drug effects Glucocorticoids / pharmacology* Hippocampus / chemistry, physiology Nerve Growth Factors / drug effects, genetics* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS01675/NS/NINDS NIH HHS; NS29664/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Nerve Growth Factors; 0/RNA, Messenger; 103107-01-3/Fibroblast Growth Factor 2; 50-02-2/Dexamethasone; 50-22-6/Corticosterone; 52-39-1/Aldosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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