| Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondria. | |
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MedLine Citation:
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PMID: 9755852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The importance of mitochondria is rising as a target in pathologic processes such as ischemia. We have investigated the effects of hydrocortisone, prednisolone, dexamethasone and triamcinolone on oxidative phosphorylation, Ca2+ fluxes, swelling and membrane potentials in isolated kidney mitochondria. The measurement of respiration state 3 showed a significant decrease in presence of glucocorticoids whereas the other respiration states were not modified. When mitochondria were uncoupled and either the complexes III and IV or the complex IV were stimulated, the O2 consumption was decreased by glucocorticoids. These results suggest the cytochrome c oxidase is a target of the glucocorticoid effect on the respiratory chain. Indeed, the other mitochondrial functions investigated were unchanged, ruling out a direct effect on Ca2+ fluxes or swelling. A regulation of cytochrome c oxidase activity by glucocorticoids will be of particular interest in pathology involving metabolic insult. |
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Authors:
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N Simon; P Jolliet; C Morin; R Zini; S Urien; J P Tillement |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 435 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-05 Completed Date: 1998-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 25-8 Citation Subset: IM |
Affiliation:
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Départment de Pharmacologie, Faculté de Médecine de Paris XII, Créteil, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Calcium / metabolism Dexamethasone / pharmacology Electron Transport Complex IV / drug effects*, metabolism* Enzyme Activation / drug effects Glucocorticoids / pharmacology* Hydrocortisone / pharmacology Kidney / drug effects, enzymology*, physiology Male Membrane Potentials / drug effects Mitochondria / enzymology*, physiology Mitochondrial Swelling / drug effects Oxygen Consumption / drug effects Prednisolone / pharmacology Rats Rats, Wistar Triamcinolone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 124-94-7/Triamcinolone; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 50-24-8/Prednisolone; 7440-70-2/Calcium; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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