Document Detail

Glucocorticoid-treatment does not influence the synthesis of thromboxane B2 and bicyclo-PGE2 in humans.
MedLine Citation:
PMID:  2710797     Owner:  NLM     Status:  MEDLINE    
It has been reported that the anti-inflammatory action of glucocorticoids is due to the inhibition of phospholipases. Consequently, after high-dose steroid treatment in humans a decrease in cyclooxygenase products should be expected. In 15 patients (10 males, 5 females, 29-62 y) undergoing 6-methyl-prednisolone-treatment (40-80 mg daily) for various clinical reasons and in 5 healthy volunteers (4 male, 1 female, 28-37 y) receiving 500 mg 6-methyl-prednisolone daily for 3 days plasma- and serum-thromboxane B2 (TXB2), as well as bicyclo-prostaglandin E2 (bicyclo-PGE2) were monitored over 3 weeks. In the entire follow-up period, however, no significant change in either serum- or plasma-TXB2 or bicyclo-PGE2 could be measured in either, patients and volunteers, under glucocorticoid-treatment. These findings indicate that even high-dose glucocorticoid-treatment does not affect the serum- and plasma-metabolites of the eicosanoids examined. It is concluded that in humans a significant inhibition of phospholipases by glucocorticoids and subsequently reduced formation of cyclooxygenase products seems to be rather unlikely.
H Sinzinger; I Virgolini; F Rauscha; P Fitscha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  35     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Atherosclerosis Research Group (ASF), Austrian Academy of Sciences, Vienna.
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MeSH Terms
Dinoprostone / analogs & derivatives*,  biosynthesis,  blood
Glucocorticoids / pharmacology*
Thromboxane B2 / biosynthesis*,  blood
Reg. No./Substance:
0/Glucocorticoids; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 74158-09-1/11-deoxy-15-keto-13,14-dihydro-11 beta,16-cycloprostaglandin E2

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