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Glucocorticoid treatment does not alter early cardiac adaptations to growth restriction in preterm sheep fetuses.
MedLine Citation:
PMID:  22703419     Owner:  NLM     Status:  In-Data-Review    
Please cite this paper as: Tare M, Miller S, Wallace E, Sutherland A, Yawno T, Coleman H, Jenkin G, Parkington H. Glucocorticoid treatment does not alter early cardiac adaptations to growth restriction in preterm sheep fetuses. BJOG 2012;119:906-914. Objective  To study the consequences of glucocorticoid treatment in fetal growth restriction (FGR) on cardiac function. Setting  Laboratory. Sample  Sheep. Methods  Growth restriction was induced in sheep fetuses using single umbilical artery ligation (SUAL) on days 105-110 of gestation (term 147). Control fetuses were not ligated. Betamethasone (BM) (11.4 mg intramuscularly) or saline was administered to ewes on days 5 and 6 after surgery. Ewes were anaesthetised on day 7, the fetuses were removed, and their hearts were mounted on a Langendorff apparatus. Balloon catheters were inserted into the right and left ventricles. Outcome measures  Ventricular contractile function and infarct area following ischaemia/reperfusion. Results  The SUAL resulted in FGR (body weight 77% of control). The FGR was associated with increases in basal left ventricular pressure development and rates of contraction and relaxation. Right ventricular contraction was unaffected. Following brief ischaemia/reperfusion, the infarct area in FGR hearts was increased four-fold compared with controls. Antenatal BM resulted in a proportional increase in heart size and coronary flow, especially in FGR fetuses, and left ventricular pressure and heart rate responses to β-adrenoceptor activation were increased. Conclusions  Fetal hearts rapidly adapt to FGR to maintain substrate delivery to the brain and heart. The FGR greatly enhanced the area of ischaemia, with implications for susceptibility in postnatal life. Antenatal BM treatment does not interfere with these cardiac changes but appears to increase left ventricle β-adrenoceptor responsiveness, which may render the offspring vulnerable to subsequent cardiac dysfunction.
M Tare; Sl Miller; Em Wallace; Ae Sutherland; T Yawno; Ha Coleman; G Jenkin; Hc Parkington
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  119     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  906-14     Citation Subset:  AIM; IM    
Copyright Information:
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
Department of Physiology Department of Obstetrics and Gynaecology The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic., Australia.
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