| Glucocorticoid therapy for acute myocardial infarction. | |
MedLine Citation:
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PMID: 175621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several uncontrolled early studies established that corticosteroid administration to patients with ischemic heart disease and cardiogenic shock was relatively safe. Whether or not the glucocorticoids were of benefit or not remained unclear when mortality was used as an index of efficacy. Hemodynamically, glucocorticoids may decrease peripheral vascular resistance, increase cardiac output and coronary blood flow, but leave myocardial contractility unchanged. The mean arterial pressure may vary unpredictably. The increase in coronary blood flow may certainly be advantageous in treating patients with acute myocardial infarction. The decrease in infarct size recently reported, if confirmed in man, would also be desirable. However, there is a paucity of good data concerning the effects of corticosteroids in man postinfarction. In addition, through unproved mechanisms, the corticosteroids decrease the extent and severity of myocardial ischemic injury. While these fundamental actions may not result in improved mortality, ongoing studies suggest that minimization of ischemic injury may ultimately prove to be most rewarding in the prevention of cardiogenic shock. |
Authors:
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R J Kones |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta cardiologica Volume: 30 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 1975 |
Date Detail:
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Created Date: 1976-04-23 Completed Date: 1976-04-23 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 353-74 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adrenocorticotropic Hormone / therapeutic use Glucocorticoids / therapeutic use* Hemodynamics Humans Hydrocortisone / therapeutic use Methylprednisolone / therapeutic use Myocardial Infarction / drug therapy*, physiopathology Necrosis Shock, Cardiogenic / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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