Document Detail

Glucocorticoid therapy for acute myocardial infarction.
MedLine Citation:
PMID:  175621     Owner:  NLM     Status:  MEDLINE    
Several uncontrolled early studies established that corticosteroid administration to patients with ischemic heart disease and cardiogenic shock was relatively safe. Whether or not the glucocorticoids were of benefit or not remained unclear when mortality was used as an index of efficacy. Hemodynamically, glucocorticoids may decrease peripheral vascular resistance, increase cardiac output and coronary blood flow, but leave myocardial contractility unchanged. The mean arterial pressure may vary unpredictably. The increase in coronary blood flow may certainly be advantageous in treating patients with acute myocardial infarction. The decrease in infarct size recently reported, if confirmed in man, would also be desirable. However, there is a paucity of good data concerning the effects of corticosteroids in man postinfarction. In addition, through unproved mechanisms, the corticosteroids decrease the extent and severity of myocardial ischemic injury. While these fundamental actions may not result in improved mortality, ongoing studies suggest that minimization of ischemic injury may ultimately prove to be most rewarding in the prevention of cardiogenic shock.
R J Kones
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta cardiologica     Volume:  30     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-23     Completed Date:  1976-04-23     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  353-74     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Adrenocorticotropic Hormone / therapeutic use
Glucocorticoids / therapeutic use*
Hydrocortisone / therapeutic use
Methylprednisolone / therapeutic use
Myocardial Infarction / drug therapy*,  physiopathology
Shock, Cardiogenic / drug therapy
Reg. No./Substance:
0/Glucocorticoids; 50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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