Document Detail


Glucocorticoid receptor binding in proliferating and differentiating cells: modulation by a tumour promoting agent.
MedLine Citation:
PMID:  8298507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the tumour-promoting agent, phorbol 12-myristate 13-acetate, on dexamethasone binding and protein kinase C in proliferating and differentiating murine erythroleukemic cells were investigated. Concentration dependent changes in steroid binding were observed in proliferating and differentiating cells treated with phorbol 12-myristate 13-acetate for 2h or 24h. Ligand binding in differentiating cells was consistently lower than in proliferating cells. Reduced expression of protein kinase C was observed in differentiating cells as compared with proliferating cells; the amount of enzyme protein was reduced on treatment of cells with phorbol ester.
Authors:
G R Lavis; K D Hammond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry and molecular biology international     Volume:  31     ISSN:  1039-9712     ISO Abbreviation:  Biochem. Mol. Biol. Int.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9306673     Medline TA:  Biochem Mol Biol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  789-95     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Cell Differentiation / physiology*
Cell Division / physiology*
Dexamethasone / metabolism
Mice
Protein Kinase C / metabolism
Receptors, Glucocorticoid / drug effects,  metabolism*
Tetradecanoylphorbol Acetate / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Receptors, Glucocorticoid; 16561-29-8/Tetradecanoylphorbol Acetate; 50-02-2/Dexamethasone; EC 2.7.11.13/Protein Kinase C

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