| Glucocorticoid receptor binding in proliferating and differentiating cells: modulation by a tumour promoting agent. | |
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MedLine Citation:
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PMID: 8298507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the tumour-promoting agent, phorbol 12-myristate 13-acetate, on dexamethasone binding and protein kinase C in proliferating and differentiating murine erythroleukemic cells were investigated. Concentration dependent changes in steroid binding were observed in proliferating and differentiating cells treated with phorbol 12-myristate 13-acetate for 2h or 24h. Ligand binding in differentiating cells was consistently lower than in proliferating cells. Reduced expression of protein kinase C was observed in differentiating cells as compared with proliferating cells; the amount of enzyme protein was reduced on treatment of cells with phorbol ester. |
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Authors:
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G R Lavis; K D Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 31 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-08 Completed Date: 1994-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 789-95 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Cell Differentiation / physiology* Cell Division / physiology* Dexamethasone / metabolism Mice Protein Kinase C / metabolism Receptors, Glucocorticoid / drug effects, metabolism* Tetradecanoylphorbol Acetate / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Glucocorticoid; 16561-29-8/Tetradecanoylphorbol Acetate; 50-02-2/Dexamethasone; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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