| Glucocorticoid programming of adult disease. | |
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MedLine Citation:
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PMID: 15846507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal exposure to elevated levels of glucocorticoids can occur naturally when maternal glucocorticoids are elevated in times of stress or when exogenous glucocorticoids are administered. Epidemiological studies and animal models have shown that, whereas short-term benefits may be associated with fetal glucocorticoid exposure, long-term deleterious effects may arise. This review compares the effects of exposure to natural versus synthetic glucocorticoids and considers the ways in which the timing of the exposure and the sex of the fetus may influence outcomes. Some of the long-term effects of glucocorticoid exposure may be explained by epigenetic mechanisms. |
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Authors:
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Karen M Moritz; Wee Ming Boon; E Marelyn Wintour |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-11-03 |
Journal Detail:
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Title: Cell and tissue research Volume: 322 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 81-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Monash University, 3800 Clayton, Australia. karen.moritz@med.monash.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism Disease / etiology* Epigenesis, Genetic Female Fetus / physiology Glucocorticoids / metabolism* Humans Kidney / metabolism Maternal-Fetal Exchange Pregnancy Prenatal Exposure Delayed Effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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