Document Detail

Glucocorticoid programming of adult disease.
MedLine Citation:
PMID:  15846507     Owner:  NLM     Status:  MEDLINE    
Fetal exposure to elevated levels of glucocorticoids can occur naturally when maternal glucocorticoids are elevated in times of stress or when exogenous glucocorticoids are administered. Epidemiological studies and animal models have shown that, whereas short-term benefits may be associated with fetal glucocorticoid exposure, long-term deleterious effects may arise. This review compares the effects of exposure to natural versus synthetic glucocorticoids and considers the ways in which the timing of the exposure and the sex of the fetus may influence outcomes. Some of the long-term effects of glucocorticoid exposure may be explained by epigenetic mechanisms.
Karen M Moritz; Wee Ming Boon; E Marelyn Wintour
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-11-03
Journal Detail:
Title:  Cell and tissue research     Volume:  322     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Department of Anatomy and Cell Biology, Monash University, 3800 Clayton, Australia.
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MeSH Terms
Brain / metabolism
Disease / etiology*
Epigenesis, Genetic
Fetus / physiology
Glucocorticoids / metabolism*
Kidney / metabolism
Maternal-Fetal Exchange
Prenatal Exposure Delayed Effects*
Time Factors
Reg. No./Substance:

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