Document Detail


Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-β1-induced epithelial-to-mesenchymal transition and cell migration.
MedLine Citation:
PMID:  20971111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial-to-mesenchymal transition (EMT) has been implicated in various physiological and pathological events. In this study, we found that the synthetic glucocorticoid dexamethasone (Dex) can inhibit transforming growth factor-beta1-induced EMT and cell migration. We also demonstrated that Dex inhibits EMT through a mechanism involving the suppression of ROS generation. Surprisingly, Dex alone induced mesenchymal-to-epithelial transition (MET). Dexamethasone treatment abolished Snail1 binding to the E-cadherin promoter, suggesting that suppression of Snail1 contributes to the above roles of Dex. Our findings demonstrate that Dex functions as both a suppressor of EMT and as an inducer of MET and therefore may be implicated in certain pathophysiological events.
Authors:
Liang Zhang; Weiwei Lei; Xunde Wang; Yunneng Tang; Jianguo Song
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4646-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. 320 Yue-Yang Road, Shanghai 200031, China.
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MeSH Terms
Descriptor/Qualifier:
Cadherins / genetics
Cell Line
Cell Movement / drug effects*
Dexamethasone / pharmacology*
Epithelial Cells / cytology*
Epithelial-Mesenchymal Transition / drug effects*
Humans
Mesoderm / cytology*,  drug effects*,  metabolism
Mifepristone / pharmacology
Promoter Regions, Genetic
Reactive Oxygen Species / metabolism
Transcription Factors / metabolism
Transforming Growth Factor beta1 / pharmacology*
Chemical
Reg. No./Substance:
0/Cadherins; 0/Reactive Oxygen Species; 0/Transcription Factors; 0/Transforming Growth Factor beta1; 0/snail family transcription factors; 50-02-2/Dexamethasone; 84371-65-3/Mifepristone

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