Document Detail

Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-β1-induced epithelial-to-mesenchymal transition and cell migration.
MedLine Citation:
PMID:  20971111     Owner:  NLM     Status:  MEDLINE    
Epithelial-to-mesenchymal transition (EMT) has been implicated in various physiological and pathological events. In this study, we found that the synthetic glucocorticoid dexamethasone (Dex) can inhibit transforming growth factor-beta1-induced EMT and cell migration. We also demonstrated that Dex inhibits EMT through a mechanism involving the suppression of ROS generation. Surprisingly, Dex alone induced mesenchymal-to-epithelial transition (MET). Dexamethasone treatment abolished Snail1 binding to the E-cadherin promoter, suggesting that suppression of Snail1 contributes to the above roles of Dex. Our findings demonstrate that Dex functions as both a suppressor of EMT and as an inducer of MET and therefore may be implicated in certain pathophysiological events.
Liang Zhang; Weiwei Lei; Xunde Wang; Yunneng Tang; Jianguo Song
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4646-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. 320 Yue-Yang Road, Shanghai 200031, China.
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MeSH Terms
Cadherins / genetics
Cell Line
Cell Movement / drug effects*
Dexamethasone / pharmacology*
Epithelial Cells / cytology*
Epithelial-Mesenchymal Transition / drug effects*
Mesoderm / cytology*,  drug effects*,  metabolism
Mifepristone / pharmacology
Promoter Regions, Genetic
Reactive Oxygen Species / metabolism
Transcription Factors / metabolism
Transforming Growth Factor beta1 / pharmacology*
Reg. No./Substance:
0/Cadherins; 0/Reactive Oxygen Species; 0/Transcription Factors; 0/Transforming Growth Factor beta1; 0/snail family transcription factors; 50-02-2/Dexamethasone; 84371-65-3/Mifepristone

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