| Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-β1-induced epithelial-to-mesenchymal transition and cell migration. | |
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MedLine Citation:
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PMID: 20971111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epithelial-to-mesenchymal transition (EMT) has been implicated in various physiological and pathological events. In this study, we found that the synthetic glucocorticoid dexamethasone (Dex) can inhibit transforming growth factor-beta1-induced EMT and cell migration. We also demonstrated that Dex inhibits EMT through a mechanism involving the suppression of ROS generation. Surprisingly, Dex alone induced mesenchymal-to-epithelial transition (MET). Dexamethasone treatment abolished Snail1 binding to the E-cadherin promoter, suggesting that suppression of Snail1 contributes to the above roles of Dex. Our findings demonstrate that Dex functions as both a suppressor of EMT and as an inducer of MET and therefore may be implicated in certain pathophysiological events. |
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Authors:
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Liang Zhang; Weiwei Lei; Xunde Wang; Yunneng Tang; Jianguo Song |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4646-54 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. 320 Yue-Yang Road, Shanghai 200031, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cadherins
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genetics Cell Line Cell Movement / drug effects* Dexamethasone / pharmacology* Epithelial Cells / cytology* Epithelial-Mesenchymal Transition / drug effects* Humans Mesoderm / cytology*, drug effects*, metabolism Mifepristone / pharmacology Promoter Regions, Genetic Reactive Oxygen Species / metabolism Transcription Factors / metabolism Transforming Growth Factor beta1 / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cadherins; 0/Reactive Oxygen Species; 0/Transcription Factors; 0/Transforming Growth Factor beta1; 0/snail family transcription factors; 50-02-2/Dexamethasone; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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