Document Detail

Glucocorticoid-induced keratinocyte-derived interleukin-1 receptor antagonist(s).
MedLine Citation:
PMID:  1532379     Owner:  NLM     Status:  MEDLINE    
Pretreatment of epidermal cells (EC) with hydrocortisone or dexamethasone abolishes their capacity to produce interleukin-1 (IL-1) and therefore reduces their capacity to support proliferative response of lectin-stimulated T cells. Additionally, glucocorticoid-pretreated keratinocytes produce an inhibitor of IL-1 activity. This factor is a non-dialysable product of radioresistant epidermal cells, does not represent a non-specific inhibitor of DNA synthesis and appears to be specific for IL-1 since it did not interfere with IL-2-dependent T-cell proliferation. It affects both IL-2 production and the induction of IL-2-receptor expression. Finally, it blocks binding of IL-1 to its receptors on D10S subclone as evaluated by competitive binding assay. Thus, we have provided evidence which indicates that immunosuppressive effects of glucocorticoids in the skin may also be mediated by an IL-1 receptor antagonist(s) produced by keratinocytes.
S Stosić-Grujicić; M L Lukić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  75     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Institute for Biological Research, Faculty of Medicine, University of Belgrade, Yugoslavia.
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MeSH Terms
Binding, Competitive / immunology
Cells, Cultured
Glucocorticoids / pharmacology*
Hydrocortisone / pharmacology
Interleukin-1 / metabolism
Interleukin-2 / biosynthesis
Keratinocytes / drug effects*,  immunology*
Rats, Inbred Strains
Receptors, Immunologic / antagonists & inhibitors*
Receptors, Interleukin-1
Receptors, Interleukin-2 / analysis
Reg. No./Substance:
0/Glucocorticoids; 0/Interleukin-1; 0/Interleukin-2; 0/Receptors, Immunologic; 0/Receptors, Interleukin-1; 0/Receptors, Interleukin-2; 50-23-7/Hydrocortisone

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