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Glucocorticoid-induced enhancement of contextual fear memory consolidation in rats: involvement of D1 receptor activity of hippocampal area CA1.
MedLine Citation:
PMID:  23727402     Owner:  NLM     Status:  Publisher    
This study investigated the role of dopamine (DA) receptors in area CA1 of the hippocampus in modulating the effects of glucocorticoids on the contextual fear memory consolidation. Adult male rats were given systemic injections of corticosterone (CORT; 3mg/kg) immediately after training in a contextual fear conditioning (CFC) task and the percentage of time spent freezing in the CFC context was recorded 24h after training. Intra-CA1 infusion of the DA type 1 (D1) receptor antagonist SCH 23390 (SCH; 30ng/0.5µl per side) immediately after CORT injection attenuated CORT-induced enhancement of memory consolidation. However, intra-CA1 infusion of the DA type 2 (D2) receptor antagonist sulpiride (SUL; 60ng/0.5µl per side) was ineffective. Neither antagonist alone altered freezing behavior in the 24-h CFC retention test. Furthermore, the memory enhancing dose of CORT used in these experiments reduced D1, but not D2, receptor mRNA expression in area CA1. Neither D1 nor D2 antagonism in area CA1 affected total locomotor activity. These findings provide evidence for the involvement of hippocampal D1 receptor activity in area CA1 in CORT-induced enhancement of contextual fear memory consolidation.
Ying Liao; Yan-Wei Shi; Qiu-Ling Liu; Hu Zhao
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-28
Journal Detail:
Title:  Brain research     Volume:  -     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, P.R China. Electronic address:
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