Document Detail

Glucocorticoid-induced cataract in chick embryo monitored by Raman spectroscopy.
MedLine Citation:
PMID:  2912907     Owner:  NLM     Status:  MEDLINE    
Glucocorticoid-induced cataract lens in chick embryo was monitored by laser Raman spectroscopy. The lens opacity that appeared in chick embryo is a reversible one. Raman spectra show no significant change in the relative content of water or secondary structure of the proteins upon lens opacification. The intensity ratios of tyrosine doublet bands in Raman spectra between clear and opaque lens portions are changes. This change is reversible, and is interpreted as a protein-water phase separation that occurred during lens opacification.
A Mizuno; H Nishigori; M Iwatsuru
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  30     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-28     Completed Date:  1989-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-7     Citation Subset:  IM    
Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Body Water / metabolism
Cataract / chemically induced*,  metabolism
Chemical Phenomena
Chick Embryo / metabolism
Crystallins / metabolism
Lens, Crystalline / metabolism
Spectrum Analysis / methods
Time Factors
Tyrosine / metabolism
Reg. No./Substance:
0/Crystallins; 0/Glucocorticoids; 55520-40-6/Tyrosine

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