Document Detail

Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators.
MedLine Citation:
PMID:  11742989     Owner:  NLM     Status:  MEDLINE    
The circadian timing system in mammals is composed of a master pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus and slave clocks in most peripheral cell types. The phase of peripheral clocks can be completely uncoupled from the SCN pacemaker by restricted feeding. Thus, feeding time, while not affecting the phase of the SCN pacemaker, is a dominant Zeitgeber for peripheral circadian oscillators. Here we show that the phase resetting in peripheral clocks of nocturnal mice is slow when feeding time is changed from night to day and rapid when switched back from day to night. Unexpectedly, the inertia in daytime feeding-induced phase resetting of circadian gene expression in liver and kidney is not an intrinsic property of peripheral oscillators, but is caused by glucocorticoid signaling. Thus, glucocorticoid hormones inhibit the uncoupling of peripheral and central circadian oscillators by altered feeding time.
N Le Minh; F Damiola; F Tronche; G Schütz; U Schibler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  20     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-14     Completed Date:  2002-02-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  7128-36     Citation Subset:  IM    
Département de Biologie Moléculaire, Sciences II, Université de Genève, 30 Quai Ernest Ansermet, CH-1211 Genève, Switzerland.
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MeSH Terms
Base Sequence
Circadian Rhythm*
Corticosterone / physiology*
DNA Primers
Gene Expression Regulation / physiology
In Situ Hybridization
Kidney / metabolism
Liver / metabolism
Mice, Inbred C57BL
Receptors, Glucocorticoid / physiology
Suprachiasmatic Nucleus / physiology*
Reg. No./Substance:
0/DNA Primers; 0/Receptors, Glucocorticoid; 50-22-6/Corticosterone

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