| Glucocorticoid exposure of sheep at 0.7 to 0.75 gestation augments late-gestation fetal stress responses. | |
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MedLine Citation:
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PMID: 22192534 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: Exposure to glucocorticoid levels inappropriately high for current maturation alters fetal hypothalamo-pituitary-adrenal axis (HPAA) development. In an established fetal sheep model, we determined whether clinical betamethasone doses used to accelerate fetal lung maturation have persistent effects on fetal HPAA hypotensive-stress responses. STUDY DESIGN: Pregnant ewes received saline (n = 6) or betamethasone (n = 6); 2 × 110 μg/kg body weight doses injected 24 hours apart (106/107 and 112/113 days' gestational age, term 150 days). Basal adrenocorticotropin (ACTH) and cortisol and responses to fetal hypotension were measured before and 5 days after the first course and 14 days after the second course. RESULTS: Basal ACTH and cortisol were similar with treatment. HPAA responses to hypotension increased after the second but not first course and ACTH/cortisol ratio increased indicating central HPAA effects. CONCLUSIONS: Results demonstrate latency in the emergence of fetal HPAA hyperresponsiveness following betamethasone exposure that may explain hyperresponsiveness in full-term but not preterm neonates. |
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Authors:
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Matthias Schwab; Turhan Coksaygan; Florian Rakers; Peter W Nathanielsz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Friedrich Schiller University, Jena, Germany; Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Sciences Center, San Antonio, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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