Document Detail


Glucocorticoid exposure of sheep at 0.7 to 0.75 gestation augments late-gestation fetal stress responses.
MedLine Citation:
PMID:  22192534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Exposure to glucocorticoid levels inappropriately high for current maturation alters fetal hypothalamo-pituitary-adrenal axis (HPAA) development. In an established fetal sheep model, we determined whether clinical betamethasone doses used to accelerate fetal lung maturation have persistent effects on fetal HPAA hypotensive-stress responses.
STUDY DESIGN: Pregnant ewes received saline (n = 6) or betamethasone (n = 6); 2 × 110 μg/kg body weight doses injected 24 hours apart (106/107 and 112/113 days' gestational age, term 150 days). Basal adrenocorticotropin (ACTH) and cortisol and responses to fetal hypotension were measured before and 5 days after the first course and 14 days after the second course.
RESULTS: Basal ACTH and cortisol were similar with treatment. HPAA responses to hypotension increased after the second but not first course and ACTH/cortisol ratio increased indicating central HPAA effects.
CONCLUSIONS: Results demonstrate latency in the emergence of fetal HPAA hyperresponsiveness following betamethasone exposure that may explain hyperresponsiveness in full-term but not preterm neonates.
Authors:
Matthias Schwab; Turhan Coksaygan; Florian Rakers; Peter W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-16
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  206     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-04-24     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253.e16-22     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Betamethasone / adverse effects,  pharmacology*
Female
Fetus / drug effects
Glucocorticoids / adverse effects,  pharmacology*
Hydrocortisone / blood
Hypotension / blood,  chemically induced*
Hypothalamo-Hypophyseal System / drug effects
Pituitary-Adrenal System / drug effects
Pregnancy
Sheep
Stress, Physiological / drug effects*
Grant Support
ID/Acronym/Agency:
R01 HL068649/HL/NHLBI NIH HHS; R01 HL068649-01A2/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 9002-60-2/Adrenocorticotropic Hormone; 9842X06Q6M/Betamethasone; WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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