| Glucocorticoid excess syndromes causing hypertension. | |
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MedLine Citation:
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PMID: 3067845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adrenal glucocorticoid secretions undoubtedly perform necessary physiologic functions in maintaining normal blood pressure when secreted at their ordinary rate or in response to short term stress. Sustained glucocorticoid excess, in Cushing's syndrome or during prolonged therapy with synthetic steroids, leads to arterial hypertension and arteriosclerotic cardiovascular disease through a plentiful variety of pathogenetic mechanisms. Naturally occurring Cushing's syndrome should be readily detected, treated, and reversed unless due to metastatic malignancy. The benefits of glucocorticoid treatment as immunosuppressive and anti-inflammatory therapy are genuine, but the price includes cardiovascular disease. It is likely that the past role of glucocorticoid therapy will be supplanted by new strategies that minimize steroid dose, employ nonsteroid regimens, and perhaps lead to the development of specific steroids that possess only beneficial actions without potential for cardiovascular toxicity. |
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Authors:
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L R Krakoff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology clinics Volume: 6 ISSN: 0733-8651 ISO Abbreviation: Cardiol Clin Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1989-04-13 Completed Date: 1989-04-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8300331 Medline TA: Cardiol Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 537-45 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mount Sinai Medical Center, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocortical Hyperfunction
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complications* Cushing Syndrome / complications Glucocorticoids / adverse effects, physiology, secretion* Humans Hypertension / chemically induced, etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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