| Glucocorticoid excess and hypertension. | |
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MedLine Citation:
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PMID: 15527696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cushing's syndrome is a rare disorder characterized by chronic, excess glucocorticoid exposure. Hypertension is one of the most discriminating features of the disease, as it is present in 80% of patients. Patients with Cushing's syndrome have a mortality rate four times that of the general population, most likely secondary to an increased number of cardiovascular risk factors, including hypertension. In this article, we review several pathogenetic mechanisms of glucocorticoid-induced hypertension, including the role of sodium/water and mineralocorticoid excess, as well as involvement of the vasculature and kidney. Although treatment of hypertension with available antihypertensive medications is only moderately successful, after cure of Cushing's syndrome, approximately 30% of patients have persistent hypertension. |
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Authors:
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Smita Baid; Lynnette K Nieman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 6 ISSN: 1522-6417 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-02-03 Revised Date: 2006-07-12 |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42 MSC 1583, 10 Center Drive, Bethesda, MD 20892-1583, USA. NiemanL@nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cushing Syndrome
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complications* Glucocorticoids / adverse effects* Humans Hypertension / complications* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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