Document Detail

Glucocorticoid cytosol binding in exercise-induced sparing of muscle atrophy.
MedLine Citation:
PMID:  3700317     Owner:  NLM     Status:  MEDLINE    
Female rats were initially divided into a sedentary or an exercise group that was trained by treadmill running to a final work rate of 31 m/min, 100 min/day, for 13-18 wk. During the last 12 days of training each of these groups were further subdivided into groups that received daily subcutaneous injections of cortisol acetate (CA) (100 mg/kg body wt) or the vehicle (1% carboxymethyl cellulose). Exercise prevented approximately 40% of the gastrocnemius muscle weight loss due to CA treatment. Training did not influence glucocorticoid cytosol-receptor binding concentrations, using [3H]triamcinolone acetonide (TA) as the labeled glucocorticoid in any of the skeletal muscle types investigated. TA-receptor binding capacities were depleted by the multiple injections but were higher in the red fiber types of the CA-treated trained than those in the CA-treated sedentary animals. In a second series of experiments in which receptor depletion and repletion rates were studied using a single injection of cortisol, TA binding capacities 2 h after the cortisol injection were higher in slow-twitch red soleus muscles of trained as compared with sedentary rats (36.4 +/- 2.0 vs. 26.8 +/- 2.5 fmol/mg protein). Similar patterns of TA binding were also observed at 2 h between trained and sedentary animals in the fast-twitch red muscle types, whereas no training related differences were observed in white muscle types. Total and free serum cortisol concentrations also returned to base-line values faster in the trained animals following the single injection protocol.(ABSTRACT TRUNCATED AT 250 WORDS)
R C Hickson; T T Kurowski; G H Andrews; J A Capaccio; R T Chatterton
Related Documents :
7132647 - Alterations in anaerobic threshold as the result of endurance training and detraining.
21493747 - Effect of inspiratory muscle training intensities on pulmonary function and work capaci...
16397517 - Rapid onset and offset of circulatory adaptations to exercise training in men.
15699447 - Endurance exercise training in orthostatic intolerance: a randomized, controlled trial.
3094567 - An end-tidal sampler for use with slow response analysers during anaesthesia.
1885077 - Effect of moderate exercise on bowel habit.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  60     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-09     Completed Date:  1986-06-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1413-9     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cytosol / metabolism
Hydrocortisone / blood,  pharmacology
Muscles / drug effects,  metabolism
Muscular Atrophy / chemically induced,  metabolism,  prevention & control*
Physical Endurance
Physical Exertion*
Rats, Inbred Strains
Receptors, Glucocorticoid / metabolism*
Triamcinolone Acetonide / metabolism
Grant Support
Reg. No./Substance:
0/Receptors, Glucocorticoid; 50-23-7/Hydrocortisone; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal hypoxic ventilatory response, ventilation, and infant birth weight at 4,300 m.
Next Document:  Human diaphragmatic EMG: changes with lung volume and posture during supramaximal phrenic stimulatio...