Document Detail

Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study.
MedLine Citation:
PMID:  20371666     Owner:  NLM     Status:  MEDLINE    
CONTEXT: A common haplotype of the glucocorticoid receptor (GR) gene has been associated with increased susceptibility to coronary heart disease (CHD). Whether this haplotype predisposes to heart failure (HF) is unknown. OBJECTIVE: The objective of the study was to determine whether GR haplotype 3 is associated with HF and whether this association is explained by low-grade inflammation (C-reactive protein). DESIGN: In a prospective cohort study, participants were genotyped for common GR gene polymorphisms (ER22/23EK, BclI C/G, N363S, 9beta A/G). Haplotype analyses were conducted. SETTING: The study was conducted at one university medical center, two Veterans Affairs medical centers, and nine public health clinics. PATIENTS: Patients included 526 white outpatients with stable CHD. MAIN OUTCOME MEASURES: Echocardiographic evidence of ventricular dysfunction, self-reported heart failure, and subsequent hospitalization for heart failure were measured. RESULTS: After adjusting for age, sex, smoking, and body mass index, participants with two copies of haplotype 3 were more likely than those with 0 or 1 copy to report heart failure [hazard ratio (HR) 4.15, 95% confidence interval (CI) 1.5-11.3, P < 0.01], have systolic dysfunction (left ventricular ejection fraction <50%) (HR 3.0, 95% CI 0.9-9.9, P = 0.07), and be hospitalized for HF during a mean follow-up of 6 yr (HR 3.0, 95% CI 1.3-7.0, P = 0.01). These associations were attenuated after adjustment for higher C-reactive protein levels in patients with two copies of haplotype 3. CONCLUSIONS: We found that the GR gene haplotype 3 was associated with prevalent HF, systolic dysfunction, and subsequent HF hospitalization in patients with CHD. This association was partly mediated by low-grade inflammation.
Christian Otte; Stefan W?st; Shoujun Zhao; Ludmila Pawlikowska; Pui-Yan Kwok; Mary A Whooley
Related Documents :
16209986 - Sirolimus-eluting stent implantation in diabetic patients with multivessel coronary art...
19752326 - Perioperative risk predictors of cardiac outcomes in patients undergoing liver transpla...
11923036 - Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events i...
24122536 - Remote infarction following percutaneous transluminal septal myocardial ablation: a rep...
23991656 - Thrombus aspiration during st-segment elevation myocardial infarction.
1974366 - Superiority of substrate enhancement over oxygen free-radical scavengers during extende...
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-04-06
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2885-91     Citation Subset:  AIM; IM    
Department of Psychiatry, University Medical Center, 20246 Hamburg-Eppendorf, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism
Coronary Disease / genetics,  physiopathology
Follow-Up Studies
Heart Failure / genetics*
Hospitalization / statistics & numerical data
Hydrocortisone / urine
Inflammation / genetics*
Interleukin-6 / metabolism
Middle Aged
Polymorphism, Genetic / genetics
Receptors, Glucocorticoid / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Stroke Volume / physiology
Ventricular Dysfunction / genetics,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Receptors, Glucocorticoid; 50-23-7/Hydrocortisone; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  6-18F-Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to 123I-Metaiodobenzy...
Next Document:  Subtle cognitive impairments in patients with long-term cure of Cushing's disease.