| Glucantime susceptibility of Leishmania promastigotes under variable growth conditions. | |
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MedLine Citation:
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PMID: 7624285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth inhibition of Leishmania promastigotes by glucantime was compared in three different media. Glucantime inhibited the growth of Leishmania cultured in complex medium but did not affect parasite growth when added to cells cultured in defined or semi-defined media. Supplementation of the complex medium with biopterin partially reversed the glucantime effect in sensitive strains, although the addition of folic acid or oleic acid did not alter the activity of glucantime. Differences in fatty acid composition were observed between strains showing different degrees of glucantime susceptibility. |
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Authors:
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E S Moreira; R M Soares; M de L Petrillo-Peixoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Parasitology research Volume: 81 ISSN: 0932-0113 ISO Abbreviation: Parasitol. Res. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703571 Medline TA: Parasitol Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 291-5 Citation Subset: IM |
Affiliation:
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Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimony / pharmacology* Antiprotozoal Agents / pharmacology* Biopterin / pharmacology Cell Division Culture Media Fatty Acids / analysis Folic Acid / pharmacology Leishmania / chemistry, drug effects*, growth & development Leishmania braziliensis / chemistry, drug effects, growth & development Leishmania guyanensis / chemistry, drug effects, growth & development Meglumine / pharmacology* Oleic Acid Oleic Acids / pharmacology Organometallic Compounds / pharmacology* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 0/Culture Media; 0/Fatty Acids; 0/Oleic Acids; 0/Organometallic Compounds; 112-80-1/Oleic Acid; 133-51-7/meglumine antimoniate; 22150-76-1/Biopterin; 59-30-3/Folic Acid; 6284-40-8/Meglumine; 7440-36-0/Antimony |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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