Document Detail


Glucantime susceptibility of Leishmania promastigotes under variable growth conditions.
MedLine Citation:
PMID:  7624285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth inhibition of Leishmania promastigotes by glucantime was compared in three different media. Glucantime inhibited the growth of Leishmania cultured in complex medium but did not affect parasite growth when added to cells cultured in defined or semi-defined media. Supplementation of the complex medium with biopterin partially reversed the glucantime effect in sensitive strains, although the addition of folic acid or oleic acid did not alter the activity of glucantime. Differences in fatty acid composition were observed between strains showing different degrees of glucantime susceptibility.
Authors:
E S Moreira; R M Soares; M de L Petrillo-Peixoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasitology research     Volume:  81     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Affiliation:
Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimony / pharmacology*
Antiprotozoal Agents / pharmacology*
Biopterin / pharmacology
Cell Division
Culture Media
Fatty Acids / analysis
Folic Acid / pharmacology
Leishmania / chemistry,  drug effects*,  growth & development
Leishmania braziliensis / chemistry,  drug effects,  growth & development
Leishmania guyanensis / chemistry,  drug effects,  growth & development
Meglumine / pharmacology*
Oleic Acid
Oleic Acids / pharmacology
Organometallic Compounds / pharmacology*
Species Specificity
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Culture Media; 0/Fatty Acids; 0/Oleic Acids; 0/Organometallic Compounds; 112-80-1/Oleic Acid; 133-51-7/meglumine antimoniate; 22150-76-1/Biopterin; 59-30-3/Folic Acid; 6284-40-8/Meglumine; 7440-36-0/Antimony

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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