Document Detail


β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells.
MedLine Citation:
PMID:  23424024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno-therapeutic approaches. β-Glucans have been reported to function as potent immuno-modulators to stimulate innate and adaptive immune responses, which contributes to their antitumor property. Here, we investigated the effect of particulate β-glucans on MDSCs and found that β-glucan treatment could promote the differentiation of M-MDSCs (monocytic MDSCs) into a more mature CD11c(+) F4/80(+) Ly6C(low) population via dectin-1 pathway in vitro, which is NF-κB dependent, and the suppressive function of M-MDSCs was significantly decreased. Treatment of orally administered yeast-derived particulate β-glucan drastically downregulated MDSCs but increased the infiltrated DCs and macrophages in tumor-bearing mice, thus eliciting CTL and Th1 responses, inhibiting the suppressive activity of regulatory T cells, thereby leading to the delayed tumor progression. We show here for the first time that β-glucans induce the differentiation of MDSCs and inhibit the regulatory function of MDSCs, therefore revealing a novel mechanism for β-glucans in immunotherapy and suggesting their potential clinical benefit.
Authors:
Jie Tian; Jie Ma; Ke Ma; Hongye Guo; Samuel Essien Baidoo; Yue Zhang; Jun Yan; Liwei Lu; Huaxi Xu; Shengjun Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-25
Journal Detail:
Title:  European journal of immunology     Volume:  43     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-06-17     Revised Date:  2013-10-29    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1220-30     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang, China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antigens, CD11c / genetics,  immunology
Carcinoma, Lewis Lung / drug therapy*,  genetics,  immunology*,  pathology
Cell Differentiation / drug effects*
Cell Movement / drug effects
Dendritic Cells / drug effects,  immunology,  pathology
Fungal Polysaccharides / isolation & purification,  pharmacology*
Gene Expression Regulation, Neoplastic / drug effects
Immunologic Factors / isolation & purification,  pharmacology*
Immunosuppression
Lectins, C-Type / genetics,  immunology
Macrophages / drug effects,  immunology,  pathology
Mice
Myeloid Cells / drug effects*,  immunology,  pathology
NF-kappa B / genetics,  immunology
Saccharomyces cerevisiae / chemistry
Spleen / drug effects,  immunology,  pathology
T-Lymphocytes, Cytotoxic / drug effects,  immunology,  pathology
T-Lymphocytes, Regulatory / drug effects,  immunology,  pathology
beta-Glucans / isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Antigens, CD11c; 0/Fungal Polysaccharides; 0/Immunologic Factors; 0/Lectins, C-Type; 0/NF-kappa B; 0/beta-Glucans; 0/dectin 1

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