Document Detail


Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat.
MedLine Citation:
PMID:  10063918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine the mechanisms implicated in the gastrointestinal inhibition induced by ovoalbumin hydrolysate infused intraluminally. We studied the site of action, the possible implication of GLP-1, and the nervous mechanisms involved. We prepared anesthetized Sprague-Dawley rats with strain gauges in the antrum, duodenum, and proximal jejunum and a catheter in the duodenum or ileum for peptone infusion. Both intraduodenal (N = 6) and intraileal (N = 5) infusion of ovoalbumin hydrolysate induced inhibition of spontaneous motor activity in the antrum, duodenum, and proximal jejunum. Duodenal inhibition induced by intraduodenal (N = 6) or intraileal (N = 6) infusion of ovoalbumin hydrolysate was reversed by intraarterial infusion of GLP-1 receptor antagonist, exendin (9-39) (3 x 10(-8) mol/kg/40 min). Finally, a combination of the adrenergic blockers phentolamine and propranolol (1 mg/kg, each; N = 7) completely blocked inhibitory gastrointestinal motor actions caused by intraduodenal infusion of ovoalbumin hydrolysate. This study demonstrates that peptone, intraluminally infused, participates in the regulation of gastrointestinal motility through stimulation of adrenergic pathways in anaesthetized rats. Moreover, these effects are partly mediated by GLP-1 secretion. The ileum seems to be the site of action, indicating a role of GLP-1 on the ileal break mechanism.
Authors:
M Giralt; P Vergara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  44     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-03-19    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  322-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Cell Biology and Physiology, Universitat Autònoma de Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Animals
Duodenum / drug effects,  physiology
Gastrointestinal Motility / drug effects*
Glucagon / physiology*
Glucagon-Like Peptide 1
Ileum / drug effects,  physiology*
Jejunum / drug effects,  physiology
Male
Ovalbumin / administration & dosage,  pharmacology
Peptide Fragments / physiology*
Peptones / administration & dosage*,  pharmacology
Phentolamine / pharmacology
Propranolol / pharmacology
Protein Hydrolysates / pharmacology
Protein Precursors / physiology*
Pyloric Antrum / drug effects,  physiology
Rats
Rats, Sprague-Dawley
Receptors, Glucagon / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Peptide Fragments; 0/Peptones; 0/Protein Hydrolysates; 0/Protein Precursors; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 50-60-2/Phentolamine; 525-66-6/Propranolol; 89750-14-1/Glucagon-Like Peptide 1; 9006-59-1/Ovalbumin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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