Document Detail


Glucagon therapy in acute pancreatitis. Report of a double-blind trial.
MedLine Citation:
PMID:  344159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-treated (n = 30) subjects for the following data: duration of pain left spontaneously and induced by palpation, amounts of analgesics and antispasmodics required by the patients, duration of hospital stay, amylase activities in serum and 24 hour urine collections. Mortality rates did not differ significantly between the glucagon-treated and the placebo-treated subjects in the total group of 69 patients and in the two subgroups of patients who were treated conservatively (n = 59) and those who underwent laparotomy because of severe peritonitis (n = 10). From the results of this study it is concluded that favourable effects of glucagon upon the course of acute pancreatitis--if they do exist--are not significant.
Authors:
H K Dürr; D Maroske; O Zelder; J C Bode
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Gut     Volume:  19     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Amylases / blood,  urine
Clinical Trials as Topic
Double-Blind Method
Female
Follow-Up Studies
Glucagon / therapeutic use*
Humans
Male
Middle Aged
Pancreatitis / drug therapy*,  mortality
Chemical
Reg. No./Substance:
9007-92-5/Glucagon; EC 3.2.1.-/Amylases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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