Document Detail

Glucagon-stimulating activity of 20 amino acids in dogs.
MedLine Citation:
PMID:  4639019     Owner:  NLM     Status:  MEDLINE    
The effect of 20 L-amino acids upon pancreatic glucagon secretion has been studied in conscious dogs. Each amino acid was administered intravenously over a 15 min period in a dose of 1 mmole/kg of body weight to a group of four or five dogs. Pancreatic glucagon and insulin were measured by radioimmunoassay. 17 of the 20 amino acids caused a substantial increase in plasma glucagon. Asparagine had the most glucagon-stimulating activity (GSA), followed by glycine, phenylalanine, serine, aspartate, cysteine, tryptophan, alanine, glutamate, threonine, glutamine, arginine, ornithine, proline, methionine, lysine, and histidine. Only valine, leucine, and isoleucine failed to stimulate glucagon secretion, and isoleucine may have reduced it. No relationship between glucagon-stimulating activity and insulin-stimulating activity was observed. The amino acids which enter the gluconeogenic pathway as pyruvate and, which are believed to provide most of the amino acid-derived glucose, had a significantly greater GSA than the amino acids which enter as succinyl CoA or as alpha-ketoglutarate. However, pyruvate itself did not stimulate glucagon secretion. The R-chain structure of the amino acid did not appear to be related to its GSA, except that the aliphatic branched chain amino acids, valine, leucine, and isoleucine, were devoid of GSA.
D M Rocha; G R Faloona; R H Unger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  51     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1972 Sep 
Date Detail:
Created Date:  1973-02-07     Completed Date:  1973-02-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2346-51     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / administration & dosage,  metabolism,  pharmacology*
Blood Glucose / analysis
Glucagon / blood,  secretion*
Injections, Intravenous
Insulin / blood,  secretion
Iodine Isotopes
Pancreas / drug effects
Pyruvates / administration & dosage,  pharmacology
Stimulation, Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Iodine Isotopes; 0/Pyruvates; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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