Document Detail


Glucagon-stimulated phosphorylation of mitochondrial and lysosomal membranes of rat liver in vivo.
MedLine Citation:
PMID:  4337238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pancreatic hormone, glucagon, stimulates the net uptake of inorganic (32)P in vivo into rat liver and its incorporation into proteins of microsomes, mitochondrial membranes, and lysosomes. Incorporation into cytosolic proteins was enhanced only slightly by glucagon. More than 95% of the protein-bound phosphate is present as phosphoserine. Both the radioactivity and the total amount of protein-bound phosphate are increased after injection of glucagon. Glucagon treatment enhanced (32)P incorporation into the alcohol-ether soluble lipids of mitochondria but did not alter the relative distribution of (32)P in various phospholipid species.
Authors:
R N Zahlten; A A Hochberg; F W Stratman; H A Lardy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  69     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1972 Apr 
Date Detail:
Created Date:  1972-07-20     Completed Date:  1972-07-20     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  800-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Animals
Butyrates / pharmacology
Chromatography, Paper
Cyclic AMP / pharmacology
Fasting
Glucagon / pharmacology*
Lipids / analysis
Liver / cytology*
Lysosomes / analysis,  metabolism*
Male
Membranes / drug effects,  metabolism*
Mitochondria, Liver / analysis,  metabolism*
Oxidative Phosphorylation / drug effects
Phosphates / analysis
Phosphorus Isotopes
Protein Binding / drug effects
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Butyrates; 0/Lipids; 0/Phosphates; 0/Phosphorus Isotopes; 60-92-4/Cyclic AMP; 9007-92-5/Glucagon
Comments/Corrections

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