Document Detail


Glucagon: the renewal of an old hormone in the pathophysiology of diabetes.
MedLine Citation:
PMID:  23302052     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Type 2 diabetes is one of the most common diseases affecting 5 to 10% of the population in most countries; the progression of its prevalence is constant over the last 50 years in all countries of the world creating a major public health problem in term of disease management and financial burden. Although the pathophysiology of type 2 diabetes has been attributed for decades to insulin resistance and decreased insulin secretion, particularly in response to glucose, the contributing role of glucagon in hyperglycemia has been highlighted since the early 70's by demonstrating its glycogenolytic, gluconeogenic and ketogenic properties. More recently, the importance of glucagon in diabetes has been highlighted in a model of streptozotocin-induced diabetic mice becoming euglycemic in the absence of glucagon receptors and without insulin treatment. Understanding the dysregulation of α cells in diabetes will be critical to better define the pathophysiology of diabetes and develop new anti-diabetic treatment. © 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Authors:
Yvan Gosmain; Mounia Heddad Masson; Jacques Philippe
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Service of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland.
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