| Glucagon-like peptide 1 and appetite. | |
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MedLine Citation:
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PMID: 23332584 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity. |
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Authors:
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Megan J Dailey; Timothy H Moran |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: - ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: mdailey5@jhmi.edi. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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