Document Detail


Glucagon-like peptide 1 and appetite.
MedLine Citation:
PMID:  23332584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity.
Authors:
Megan J Dailey; Timothy H Moran
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-16
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  24     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-20     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Appetite / physiology*
Eating / physiology
Gastrointestinal Motility / physiology
Glucagon-Like Peptide 1 / metabolism*
Humans
Grant Support
ID/Acronym/Agency:
F32 DK092126/DK/NIDDK NIH HHS; P30 DK079637/DK/NIDDK NIH HHS; R01 DK019302/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
89750-14-1/Glucagon-Like Peptide 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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