| Glucagon levels and ketogenesis in human diabetes following total or partial pancreatectomy and severe chronic pancreatitis. | |
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MedLine Citation:
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PMID: 7004039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In three groups of patients with insulin-dependent diabetes following total (n = 5) or partial (n = 5) pancreatectomy or chronic pancreatitis (n = 7) and in a group of idiopathic diabetics, ketogenic capacity following insulin withdrawal and during a 24-h fast was studied. Basal glucagon values were significantly increased in all diabetic groups with no significant intergroup differences. Basal ketone body values and their increase during starvation and insulin withdrawal were high and not different in totally pancreatectomized and primary diabetics, both showing unmeasurable C-peptide levels. On the contrary, ketogenesis was reduced in partially pancreatectomized and in pancreatitis diabetics with persistent levels of C-peptide. Our data confirmed the persistence of immunoreactive glucagon after pancreatectomy and demonstrated that ketogenesis is not suppressed in pancreatectomized diabetics and depends above all on residual B-cell function. A possible ketogenic effect of extra-pancreatic glucagon-like substances cannot be excluded. |
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Authors:
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S Del Prato; F Riva; A Devidé; R Nosadini; D Fedele; A Tiengo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta diabetologica latina Volume: 17 ISSN: 0001-5563 ISO Abbreviation: Acta Diabetol Lat Publication Date: 1980 Apr-Jun |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0123567 Medline TA: Acta Diabetol Lat Country: ITALY |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Diabetes Complications Diabetes Mellitus / blood*, drug therapy Fasting Glucagon / blood* Humans Insulin / therapeutic use Ketone Bodies / blood* Pancreatectomy* Pancreatitis / blood*, complications |
| Chemical | |
Reg. No./Substance:
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0/Ketone Bodies; 11061-68-0/Insulin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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