Document Detail

Glucagon-induced densensitization: correlation between cyclic AMP levels and contractile force.
MedLine Citation:
PMID:  6282597     Owner:  NLM     Status:  MEDLINE    
Desensitization of guinea pig left atria to the inotropic effects of glucagon was produced in vitro by treatment of the atria with 10(-6) M glucagon for 2 or 15 min. Desensitization of the contractile response was associated with a loss of the ability of glucagon to elevate cyclic AMP levels. A highly significant correlation was found between the increase in contractile force and the increase in cyclic AMP levels in control and glucagon desensitized left atria.
L F Yao; K M MacLeod; J H McNeill
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  79     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
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MeSH Terms
Cyclic AMP / metabolism*
Glucagon / pharmacology*
Guinea Pigs
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Time Factors
Reg. No./Substance:
60-92-4/Cyclic AMP; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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