| Glucagon-induced Pheochromocytoma Crisis: Case Report and Literature Review. | |
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MedLine Citation:
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PMID: 21324811 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To report a previously asymptomatic woman, who developed glucagon-induced pheochromocytoma crisis during preparation for elective colonoscopy.Methods: The clinical features, laboratory and imaging findings as well as outcome are presented and the related literature is reviewed.Results: A 76-year-old woman received glucagon prior to routine colonoscopy to inhibit intestinal motility. She immediately developed severe hypertension, cardiac arrhythmias and altered mental status. Her hospital course was complicated by encephalopathy, cardiac, respiratory, renal and hepatic failure. A CT scan of abdomen revealed a 6.5 × 4.8 cm mass in the left adrenal gland. Lab results for vanillyl mandelic acid (VMA), catecholamines and metanephrines were markedly elevated. She underwent a successful laparoscopic left adrenalectomy. Histopathology of the adrenal mass was diagnostic of a pheochromocytoma.Conclusion: Glucagon administration activated an occult pheochromocytoma causing multi-organ injury due to a catecholamine crisis. It is imperative that health care providers using glucagon be conscious of this rare but life-threatening complication. |
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Authors:
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Alireza Hosseinnezhad; Robert M Black; Narothama Reddy Aeddula; Deep Adhikari; Nitin Trivedi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-16 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-10 Citation Subset: - |
Affiliation:
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Department of Medicine, Saint Vincent Hospital, Worcester, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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