Document Detail


Glucagon-Like Peptide 1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells.
MedLine Citation:
PMID:  25433659     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic β-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase mitochondrial biogenesis in pancreatic β-cells. We treated INS-1 rat insulinoma cells with GLP-1 or exendin-4 for 48 hours and measured mitochondrial mass and function. Both GLP-1 and exendin-4 increased mitochondrial mass by approximately 20%. The mitochondria/cytosol ratio was increased from 7.60%±3.12% to 10.53%±2.70% by exendin-4. In addition, GLP-1 increased the mitochondrial membrane potential and oxygen consumption. Proliferator-activated receptor-gamma coactivator 1α expression was increased approximately 2-fold by GLP-1 treatment. In conclusion, the present study presents evidence for a new mechanism of action by which GLP-1 improves pancreatic β-cell function via enhanced mitochondrial mass and performance.
Authors:
Mi Yeon Kang; Tae Jung Oh; Young Min Cho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-26
Journal Detail:
Title:  Endocrinology and metabolism (Seoul, Korea)     Volume:  -     ISSN:  2093-596X     ISO Abbreviation:  Endocrinol Metab (Seoul)     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-30     Completed Date:  -     Revised Date:  2014-12-1    
Medline Journal Info:
Nlm Unique ID:  101554139     Medline TA:  Endocrinol Metab (Seoul)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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