Document Detail


The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension.
MedLine Citation:
PMID:  15480095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cardiac and vascular remodeling occur in response to hypertension. Genetic background appears to modify the development of target organ damage (TOD). We evaluated the impact on hypertension-associated TOD of a highly polymorphic gene with elevated significance for the regulation of the cardiovascular system, the beta2AR gene. METHODS: We recruited 775 hypertensives (mean +/- SE: age 53.5 +/- 0.5, from 20 to 84 years; female 32.7%; systolic (SBP)/diastolic (DBP) blood pressure: 159 +/- 1.2/101 +/- 0.6 mmHg) referred to the departmental outpatient clinic and screened them for the Arg16Gly, Gln27Glu, and Ile164Thr variants of beta2AR gene. We performed association analyses on clinical, anamnesis, anthropometrical and biochemical parameters as well as cardiac and vascular ultrasound. RESULTS: We found that the three polymorphisms did not affect blood pressure levels. Cardiac TOD appeared to be related to the Glu27 variant. In fact, the Glu27 allele associates with a 1.4-fold higher risk of developing cardiac hypertrophy, and directly correlated with larger systolic and diastolic left ventricle internal diameters. Vascular TOD was not affected by the three polymorphisms. Ancillary to our finding we observed that the Glu27 variant is associated with a higher incidence of dyslipidemia. CONCLUSIONS: Our data indicate that beta2AR gene polymorphisms participate in the determination of cardiac TOD associated with hypertension.
Authors:
Guido Iaccarino; Francesca Lanni; Ersilia Cipolletta; Valentina Trimarco; Raffaele Izzo; Gianni Luigi Iovino; Nicola De Luca; Bruno Trimarco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  22     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-13     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2117-22     Citation Subset:  IM    
Affiliation:
Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cardiomegaly / epidemiology*,  genetics*,  ultrasonography
Female
Genetic Predisposition to Disease / epidemiology
Genotype
Humans
Hyperlipidemias / epidemiology,  genetics
Hypertension / epidemiology*,  genetics*
Incidence
Male
Middle Aged
Polymorphism, Genetic
Receptors, Adrenergic, beta-2 / genetics*
Risk Factors
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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