Document Detail


Glottic-modulated lung ventilation during continuous transtracheal gas insufflation: an experimental study.
MedLine Citation:
PMID:  12771619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated a new method of pulmonary ventilation that included a minitracheostomy, a reverse thrust catheter to deliver continuous flow of gas to the carina, and a threshold valve to avoid lung overinflation. In six lightly sedated healthy sheep, at a continuous flow of 5, 10, or 15 L/min and a threshold valve of 5, 10, 15, or 20 cm H(2)O, we observed a novel respiratory pattern that was characterized either by active lung inflation followed by passive and prolonged inspiratory hold (mixed pattern) or by an absence of all active inspiratory effort and only passive inflation of the lungs (passive pattern). We correlated airway pressure changes with direct visualization of the glottic opening through a fiberoptic bronchoscope. We measured airway pressures at the level of the carina, the subglottic level, and in the pleural space, and respiratory events were monitored through inductive plethysmography. An increase in continuous flow, threshold valve, or both resulted in 1) an increase in glottic breathing; 2) a decrease in respiratory rate, with a decrease in inspiratory pleural pressure excursion; or 3) an increased inspiratory/expiratory ratio and mean airway pressure. During transtracheal gas insufflation, as in this study, a novel respiratory pattern evolved that was modulated by the glottis, accompanied by a decreased effort of breathing; coughing and swallowing remained, and vocalization remained unimpaired.
Authors:
Nicolo Patroniti; Muriel Verweij; Theodor Kolobow
Related Documents :
24691439 - Ocular-specific er stress reduction rescues glaucoma in murine glucocorticoid-induced g...
10834249 - Autonomic control of the heart during circular breathing.
6415019 - Within-breath pco2 levels in the airways and at the pulmonary stretch receptor sites.
705069 - Occlusion pressure in acute bronchospasm induced by methylcholine.
66039 - Relationships between eupnoeic pattern of breathing and ventilatory control in man ii. ...
7813279 - Work of breathing after extubation.
9020529 - The effect of pentagastrin, cholecystokinin and their analogues on rat arterial blood p...
1328979 - A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intr...
19012209 - Tricuspid valve replacement: an analysis of risk factors and outcomes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  31     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-06-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1461-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgical Science and Intensive Care, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. nicolo.patroniti@unimib.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Airway Resistance
Animals
Bronchoscopy
Cough / physiopathology
Deglutition / physiology
Equipment Design
Female
Glottis / physiology*
Insufflation / instrumentation,  methods*
Models, Animal
Monitoring, Physiologic
Oxygen Inhalation Therapy / instrumentation,  methods*
Plethysmography
Pressure
Respiration, Artificial / instrumentation,  methods*
Respiratory Mechanics / physiology*
Sheep
Tracheostomy* / methods
Video Recording
Vocalization, Animal / physiology
Work of Breathing / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and ...
Next Document:  Methylprednisolone inhibits low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused ...