| Glottic carcinoma--patterns of failure and salvage treatment after curative radiotherapy in 861 consecutive patients. | |
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MedLine Citation:
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PMID: 12142089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The aim of this study was to evaluate the patterns of failure and the treatment of recurrences, in a series of primary irradiated patients with squamous cell carcinoma of the glottic larynx. MATERIALS AND METHODS: Eight hundred and sixty-one consecutive patients were included in this study from 1963 to 1991, out of which 74 were females and 787 males. The stages were: I 56, II 26, III 15, and IV 3%. In 847 of 861 cases (98%) the primary treatment was delivered with curative intent, and out of these 834 patients received primary radical radiotherapy. RESULTS: With a minimum follow up of 5 years, 274/861(32%) patients had persistent or recurrent disease; in 91% of these the persistent or recurrent disease was in the T-position, 15% in the N-position, and 5% developed distant metastases. Curative salvage attempt was possible in 207 patients, and 145 were subsequently controlled. A total of 718 (83%) patients obtained ultimate tumour control, 584 (68%) without a laryngectomy (134 of the controlled had a laryngectomy, 109 had a total laryngectomy and 25 had a partial laryngectomy). In the patients treated with curative intent, the overall 5-year local tumour control, loco-regional tumour control, disease specific survival rate and overall survival rate was 72, 70, 86 and 66%, respectively. For patients with small tumours the disease specific survival for T1a, T1b and T2 was 95, 93 and 83%, respectively. In the 718 patients cured for their glottic carcinoma, 204 new primary malignant tumours were detected. CONCLUSIONS: The study shows that laryngeal glottic carcinoma can be effectively managed by primary radiotherapy and surgery salvage. The control is obtained with a high proportion of laryngeal preservation (68%). Recurrences treated with surgical salvage have a success rate of 70%. New primaries are a major problem. |
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Authors:
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Lars Vendelbo Johansen; Cai Grau; Jens Overgaard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 63 ISSN: 0167-8140 ISO Abbreviation: Radiother Oncol Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-26 Completed Date: 2002-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: Ireland |
Other Details:
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Languages: eng Pagination: 257-67 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Department of Experimental Clinical Oncology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Carcinoma, Squamous Cell / mortality, radiotherapy* Female Glottis* Humans Laryngeal Neoplasms / mortality, radiotherapy* Male Neoplasm Recurrence, Local / radiotherapy, surgery Neoplasm Staging Palliative Care Prognosis Salvage Therapy Survival Rate Tracheotomy Treatment Failure |
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