Document Detail


Glomus jugulare tumours: certain clinical and radiological aspects observed following Gamma Knife radiosurgery.
MedLine Citation:
PMID:  19296050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Glomus jugulare tumours represent a great therapeutic challenge. Previous papers have documented good results from Gamma Knife surgery (GKS) with these tumours. However, the relationship between clinical improvement and tumour shrinkage has never been assessed. MATERIALS AND METHODS: There were 14 patients, 9 women and 5 men. The mean follow-up period was 28 months (range 6 to 60 months). All the tumours except one were Fisch type D and the mean volume was 14.2 cm(3) (range 3.7-28.4 cm(3)). The mean prescription dose was 13.6 Gy (range 12-16 Gy). RESULTS: None of the tumours have continued to grow. Eight are smaller and 6 unchanged in volume. Two patients with bruit have had no improvement in their symptoms. Among the other 12 patients, 5 have had symptomatic improvement of dysphagia, 4 in dysphonia, 3 in facial numbness, 3 in ataxia and 2 in tinnitus. Individual patients have experienced improvement in vomiting, vertigo, tongue fasciculation, hearing, headache, facial palsy and accessory paresis. One patient developed a transient facial palsy. Symptomatic improvement commonly began before any reduction in tumour volume could be detected. The mean time to clinical improvement was 6.5 months whereas the mean time to shrinkage was 13.5 months. CONCLUSIONS: Gamma Knife treatment of glomus jugulare tumours is associated with a high incidence of clinical improvement with few complications, using the dosimetry recorded here. Clinical improvement would seem to be a more sensitive early indicator of therapeutic success than radiological volume reduction. Further follow-up will be needed.
Authors:
J C Ganz; Khalid Abdelkarim
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-03-19
Journal Detail:
Title:  Acta neurochirurgica     Volume:  151     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-05-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  423-6     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Haukeland University Hospital, Nevrokirurgisk Avdeling, Haukeland Sykehus, 5021, Bergen, Norway. jcganz@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Female
Follow-Up Studies
Glomus Jugulare Tumor / diagnosis*,  surgery*
Humans
Image Enhancement / methods
Magnetic Resonance Imaging
Male
Radiosurgery*
Treatment Outcome
Comments/Corrections
Comment In:
Acta Neurochir (Wien). 2009 May;151(5):419-21   [PMID:  19296051 ]

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