Document Detail


Glomerulotubular balance and prostaglandin synthesis.
MedLine Citation:
PMID:  6422526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have tested a hypothesis proposed to explain glomerulotubular balance (GTB) as a consequence of variations in prostaglandin synthesis. Arachidonic acid (40 micrograms x kg-1 x min-1) infused into the renal artery of anesthetized dogs raised renal blood flow (RBF) by 41 +/- 5% in hydropenic and by 24 +/- 11% in volume-expanded dogs, but the absolute changes were similar. The infusion of arachidonic acid after the administration of indomethacin (10 mg x kg-1) had no effect on RBF. Arachidonic acid infusion increased the excretion of sodium and chloride in hydropenic dogs but not after the administration of ethacrynic acid in volume-expanded dogs. During continued infusion of ethacrynic acid, the glomerular filtration rate (GFR) was lowered by suprarenal aortic constriction and raised by carotid constriction. A linear relationship between electrolyte reabsorption and GFR (GTB) was observed when GFR was varied between 20 and 110% of control. GTB and tubular reabsorption at comparable GFR were not significantly altered during arachidonic acid infusion or after indomethacin administration. In all experimental settings, bicarbonate, chloride, and sodium reabsorption were altered in molar ratios of 1:2:3 during variations in GFR. We conclude that GTB is independent of variations in prostaglandin synthesis.
Authors:
H Langberg; A Hartmann; A Vikse; F Kiil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal physiology     Volume:  7     ISSN:  0378-5858     ISO Abbreviation:  Ren Physiol     Publication Date:  1984  
Date Detail:
Created Date:  1984-04-17     Completed Date:  1984-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901911     Medline TA:  Ren Physiol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid
Arachidonic Acids / pharmacology
Dogs
Ethacrynic Acid / pharmacology
Female
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Indomethacin / pharmacology
Kidney Glomerulus / physiology*
Kidney Tubules, Proximal / physiology*
Male
Natriuresis
Prostaglandins / biosynthesis*
Renal Circulation / drug effects
Water-Electrolyte Balance
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 58-54-8/Ethacrynic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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