Document Detail

Glomerulotubular balance and prostaglandin synthesis.
MedLine Citation:
PMID:  6422526     Owner:  NLM     Status:  MEDLINE    
We have tested a hypothesis proposed to explain glomerulotubular balance (GTB) as a consequence of variations in prostaglandin synthesis. Arachidonic acid (40 micrograms x kg-1 x min-1) infused into the renal artery of anesthetized dogs raised renal blood flow (RBF) by 41 +/- 5% in hydropenic and by 24 +/- 11% in volume-expanded dogs, but the absolute changes were similar. The infusion of arachidonic acid after the administration of indomethacin (10 mg x kg-1) had no effect on RBF. Arachidonic acid infusion increased the excretion of sodium and chloride in hydropenic dogs but not after the administration of ethacrynic acid in volume-expanded dogs. During continued infusion of ethacrynic acid, the glomerular filtration rate (GFR) was lowered by suprarenal aortic constriction and raised by carotid constriction. A linear relationship between electrolyte reabsorption and GFR (GTB) was observed when GFR was varied between 20 and 110% of control. GTB and tubular reabsorption at comparable GFR were not significantly altered during arachidonic acid infusion or after indomethacin administration. In all experimental settings, bicarbonate, chloride, and sodium reabsorption were altered in molar ratios of 1:2:3 during variations in GFR. We conclude that GTB is independent of variations in prostaglandin synthesis.
H Langberg; A Hartmann; A Vikse; F Kiil
Related Documents :
2353926 - Tentative identification of the toxohormones of cancer cachexia: roles of vasopressin, ...
8503706 - The production of prostanoids and the identification of macrophages in human decidua ve...
10574646 - Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory ef...
1449796 - Biosynthesis of prostaglandins by human spermatozoa in vitro and their role in acrosome...
2759666 - Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid ag...
3708986 - Hyaluronic acid and its effect on postoperative adhesions in the rabbit flexor tendon. ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal physiology     Volume:  7     ISSN:  0378-5858     ISO Abbreviation:  Ren Physiol     Publication Date:  1984  
Date Detail:
Created Date:  1984-04-17     Completed Date:  1984-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901911     Medline TA:  Ren Physiol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology
Ethacrynic Acid / pharmacology
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Indomethacin / pharmacology
Kidney Glomerulus / physiology*
Kidney Tubules, Proximal / physiology*
Prostaglandins / biosynthesis*
Renal Circulation / drug effects
Water-Electrolyte Balance
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 58-54-8/Ethacrynic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physiopathology of acute decompensation in chronic obstructive respiratory insufficiency
Next Document:  Influence of extracellular pH upon the ionic and secretory response to gliclazide in pancreatic isle...