| Glomerulonephritis in congenital cytomegalic inclusion disease. | |
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MedLine Citation:
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PMID: 3019866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Except for renal transplant recipients, glomerulonephritis has only very rarely been associated with renal cytomegalovirus (CMV) infection. The kidneys of five infants with congenital cytomegalic inclusion disease, including renal infection, were examined at autopsy. Two of the infants had glomerulonephritis. The younger, a 4-month-old female, had diffuse proliferative and necrotizing glomerulonephritis; virus was present in nuclei and cytoplasm of glomerular endothelial cells and, possibly, in leukocytes as well. There were no electron-dense deposits. The other infant, a 5-month-old male, had diffuse mesangial and focal segmental proliferative and sclerosing glomerulonephritis; electron-dense mesangial deposits were seen ultrastructurally. Three additional infants (a newborn male, a 2-day-old male, a 6-week-old female), all with CMV in tubules and one with a single glomerular inclusion, had only rare glomerular abnormalities, i.e., mesangial proliferation in less than 10 per cent of glomeruli (one infant) and segmental sclerosis in less than 1 per cent of glomeruli (all three infants). Thus, congenital renal CMV infection was associated with proliferative glomerulonephritis in the two infants who survived the longest. The three with shorter survival times had only minor glomerular alterations. |
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Authors:
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D Beneck; M A Greco; H D Feiner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Human pathology Volume: 17 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-11-14 Completed Date: 1986-11-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1054-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytomegalovirus Infections
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complications,
congenital* Female Glomerulonephritis / complications*, pathology Humans Infant, Newborn Male Microscopy, Electron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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