| Glomerular lesion and increased cytokine gene expression in renal tissue in patients with decompensated nephrotic syndrome due to chronic GvHD. | |
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MedLine Citation:
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PMID: 20446793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nephrotic syndrome is a rare complication of allogeneic stem cell transplantation (alloHSCT). We present two cases of nephrotic syndrome during chronic graft-versus-host disease (GvHD) involving altered cytokine gene expression in renal tissue. A patient with acute lymphatic leukemia demonstrated nephrotic syndrome due to minimal change disease as a marker of chronic GvHD. A patient with acute lymphoblastic leukemia suffered from severe nephrotic syndrome due to membranous glomerulopathy. In the two presented cases of GvHD-linked nephrotic syndrome, increased cytokine gene expression [tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma), interleukin 2 (IL-2), IL-6, and IL-10] assessed using semiquantitative evaluation with reverse transcriptase polymerase chain reaction (RT-PCR) in situ on renal biopsy was observed. |
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Authors:
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D Kaminska; B Bernat; O Vakulenko; J Kuzniar; B Tyran; K Suchnicki; A Lange; O Mazanowska; A Halon; M Klinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 32 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 510-4 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw 50-417, Poland. dorotakaminska@interia.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytokines / genetics*, metabolism Diagnosis, Differential Gene Expression Graft vs Host Disease / complications*, genetics Humans Male Nephrosis, Lipoid / diagnosis, etiology*, genetics Nephrotic Syndrome / diagnosis, etiology*, genetics Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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