Document Detail


Glomerular filtration is reduced by high tidal volume ventilation in an in vivo healthy rat model.
MedLine Citation:
PMID:  19855906     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Mechanical ventilation has been associated with organ failure in patients with acute respiratory distress syndrome. The present study examines the effects of tidal volume (V(T)) on renal function using two V T values (8 and 27 mL/kg) in anesthetized, paralyzed and mechanically ventilated male Wistar rats. Animals were randomized into two groups of 6 rats each: V (T)8 (V(T), 8 mL/kg; 61.50 +/- 0.92 breaths/min; positive end-expiratory pressure, 3.0 cmH(2)O; peak airway pressure (PAW), 11.8 +/- 2.0 cmH(2)O), and V T27 (V(T), 27 mL/kg; 33.60 +/- 1.56 breaths/min; positive end-expiratory pressure, none, and PAW, 22.7 +/- 4.0 cmH(2)O). Throughout the experiment, mean PAW remained comparable between the two groups (6.33 +/- 0.21 vs 6.50 +/- 0.22 cmH(2)O). For rats in the V(T)27 group, inulin clearance (mL.min(-1).body weight(-1)) decreased acutely after 60 min of mechanical ventilation and even more significantly after 90 min, compared with baseline values (0.60 +/- 0.05 and 0.45 +/- 0.05 vs 0.95 +/- 0.07; P < 0.001), although there were no differences between groups in mean arterial pressure or gasometric variables. In the V(T)8 group, inulin clearance at 120 min of mechanical ventilation remained unchanged in relation to baseline values (0.72 +/- 0.03 vs 0.80 +/- 0.05). The V(T)8 and V(T)27 groups did not differ in terms of serum thiobarbituric acid reactive substances (3.97 +/- 0.27 vs 4.02 +/- 0.45 nmol/mL) or endothelial nitric oxide synthase expression (94.25 +/- 2.75 vs 96.25 +/- 2.39%). Our results show that glomerular filtration is acutely affected by high tidal volume ventilation but do not provide information about the mechanism.
Authors:
A Luque; M H M Shimizu; L Andrade; T R Sanches; A C Seguro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  42     ISSN:  1414-431X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1104-9     Citation Subset:  IM    
Affiliation:
LIM/12, Departamento de Nefrologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. aleluque@terra.com.br
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