| Glomerular filtration rate in normal and abnormal pregnancies. | |
MedLine Citation:
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PMID: 10192245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During normal pregnancy, an early, marked, and sustained increase occurs in glomerular filtration rate (GFR) secondary to renal vasodilation. An optimal increase in GFR is a good predictor of pregnancy outcome. The pregnant rat provides an excellent model of the gestational renal hemodynamic response, and invasive studies in this species have extended our understanding of the glomerular hemodynamic mechanisms involved. Of note, the chronic renal vasodilation of pregnancy is not associated with glomerular hypertension, and pregnancy has no long-term injurious effects when kidney function is normal. The renal vasodilatory response to pregnancy is robust and persists in a range of mild renal diseases and in renal transplant recipients. When maternal renal function is moderately or severely compromised, however, the renal responses during pregnancy are often attenuated, and pregnancy may also accelerate the course of the renal disease. Studies in the rat have indicated a wide range of possible renal hemodynamic responses to pregnancy in rats with underlying kidney damage, which seem to be disease specific. Irrespective of the renal vascular response to pregnancy, there is no evidence to date suggesting that pregnancy leads to glomerular hypertension. |
Authors:
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C Baylis |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 19 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-19 Completed Date: 1999-05-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 133-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, West Virginia University Health Sciences Center, Morgantown, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Glomerular Filtration Rate / physiology* Humans Kidney Glomerulus / blood supply, physiopathology* Pregnancy / physiology* Pregnancy Complications / physiopathology* Rats Renal Circulation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL31933/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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