Document Detail

Glomerular filtration rate in endurance athletes.
MedLine Citation:
PMID:  18469573     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The interpretation of biochemical testing in sportsmen requires caution. Although creatinine-based estimates of glomerular filtration rate (GFR) overcome some shortcomings of serum creatinine, there is scarce information on their use in endurance athletes. DESIGN: We evaluated GFR, estimated by the recommended Modification of Diet in Renal Disease (MDRD) equation in athletes. PARTICIPANTS: Seventy-six professional male cyclists, 71 amateur male cyclists, and 65 healthy sedentary matched controls were included in the study. RESULTS: The mean serum creatinine level was significantly higher in the sedentary subjects (81 microM) than in amateur (75 microM; P < 0.001) and professional cyclists (72 microM; P < 0.001), and it was also marginally higher in amateur than in professional cyclists (P = 0.049). The mean estimated GFR value increased throughout the three subgroups, being significantly lower in the sedentary population (98 mL.min.[1.73 m]) than in the subgroups of amateur (109 mL.min.[1.73 m]; P < 0.001) and professional cyclists (113 mL.min.[1.73 m]; P < 0.001), but it did not differ between amateur and professional cyclists (P = 0.116). The average intensity of daily physical exercise, but not the body mass index, was inversely associated with serum creatinine and positively associated with the estimated GFR. CONCLUSIONS: The MDRD equation should be used with caution in athletes, and it should consider intensity and type of physical exercise.
Giuseppe Lippi; Giuseppe Banfi; Gian Luca Salvagno; Massimo Franchini; Gian Cesare Guidi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  18     ISSN:  1050-642X     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  286-8     Citation Subset:  IM    
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Verona, Italy.
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MeSH Terms
Bicycling / physiology
Glomerular Filtration Rate / physiology*
Hematologic Tests
Physical Endurance*
Sports / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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