Document Detail

Glomerular filtration rate and coronary artery disease burden in patients with acute coronary syndrome.
MedLine Citation:
PMID:  17803203     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mild renal dysfunction may be associated with increased cardiovascular morbidity and mortality. METHODS: The relation between estimated glomerular filtration rate (eGFR), as calculated from plasma creatinine at admission, and coronary artery disease burden (CADB), was studied in a cohort of 110 patients with acute coronary syndrome and coronary atherosclerosis. RESULTS: A relatively weak but significant negative correlation was found between eGFR and CADB as measured by angiography (coefficient correlation of - 0.26, probability value of 0.006); a similar association was seen in multiple regression analysis, taking CADB as dependent variable, and eGFR, age, plasma calcium and plasma phosphorus as independent variables. After dividing the 110 patients into eGFR tertiles (with mean values of 102.9 +/- 22.8, n = 37, 75.7 + or - 5.6, n = 36, and 53.1 +/- 13.4, n = 37, all in mL/min per 1.73 m(2)), mean CADB values of the lower and higher eGFR tertiles were found to be significantly different (270.6 +/- 176.4 and 192.9 +/- 78.5, respectively). Similar mean values for CADB and for eGFR were noted when patients with elevated ST segment/new left bundle branch block and patients with nonelevated ST segment acute coronary syndrome were compared. CONCLUSIONS: We conclude that renal function of patients with acute coronary syndromes and coronary atherosclerosis, as estimated at admission, is negatively correlated with coronary artery disease burden. It is unknown whether renal dysfunction acts as a cause for accelerated coronary artery disease or if it merely acts as a surrogate marker for the overall systemic vascular system status.
José Pedro L Nunes; Maria do Sameiro Faria; J M Mota Garcia; Francisco Rocha Gonçalves
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  30     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-12     Completed Date:  2007-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley Periodicals, Inc.
Faculty of Medicine, University of Porto, Porto, Portugal.
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MeSH Terms
Coronary Artery Disease / complications,  physiopathology*
Glomerular Filtration Rate*
Kidney Diseases / complications,  physiopathology*
Middle Aged
Predictive Value of Tests
Prospective Studies
Severity of Illness Index

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