| Glomerular basement membrane abnormalities in infants with heavy proteinuria. | |
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MedLine Citation:
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PMID: 8398650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two Indian male children with infantile-onset heavy proteinuria (with nephrotic syndrome in 1) had thickening of the glomerular basement membrane with splitting and basket-weave appearance of lamina densa on electron microscopic evaluation of kidney tissue (like Alport's syndrome), with normal light microscopic findings and negative immunofluorescence. The proteinuria was non-familial and was not associated with microhaematuria in patient 1; transient microhaematuria, perhaps associated with urinary tract infection, was noted in patient 2. There was no neurosensory deafness in the patients or their parents. The nephrotic syndrome remitted totally in one patient over a 7-month period. The proteinuria, as well as the renal disease, was non-progressive in the second patient over a 27-month period. The significance of these basement membrane abnormalities (classically described in Alport's syndrome) in early-onset nephrotic syndrome/heavy proteinuria that is non-familial and non-progressive needs to be evaluated. |
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Authors:
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K P Mehta; U S Ali; A R Chitale; U Jha; S Khubchandani |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 7 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-11-15 Completed Date: 1993-11-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 401-3 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Bai Jerbai Wadia Hospital for Children and Research Centre, Parel, Bombay, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Basement Membrane
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abnormalities*,
ultrastructure Humans Hypertrophy Infant Kidney / ultrastructure Kidney Glomerulus / abnormalities*, ultrastructure Male Nephritis, Hereditary / pathology Nephrotic Syndrome / pathology Proteinuria / pathology* |
| Comments/Corrections | |
Comment In:
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Pediatr Nephrol. 2001 Aug;16(8):688
[PMID:
11519905
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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