| Globus pharyngeus and extraesophageal reflux: simultaneous pH <4.0 and pH <5.0 analysis. | |
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MedLine Citation:
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PMID: 20938965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: Weakly acid refluxes seem to play an important role in the pathogenesis of extraesophageal reflux. The aim of this study was to evaluate how proportional representation of patients with extraesophageal reflux in a group of patients with globus pharyngeus changes when we use both pH <4.0 as well as pH <5.0 as a pathological threshold for an extraesophageal reflux episode. STUDY DESIGN: Prospective pH monitoring study of 46 patients. METHODS: Patients with pure globus pharyngeus lasting more than 3 months were included in the study. The pH monitoring was performed (Smit technique) with double probes (fixed distance of 15 cm). The recorded data using only pH <4.0 and using both pH <4.0 along with pH <5.0 as thresholds for extraesophageal reflux episode were analyzed simultaneously. The reflux area index 4 >6.3 and reflux area index 5 >72.6 were considered as clear pathological extraesophageal reflux. RESULTS: Extraesophageal reflux was proven in 23.9% patients with pure globus pharyngeus when standard analysis using only pH <4.0 was used as pathological threshold. If both pH <4.0 and pH <5.0 were used as the pathological threshold, clear extraesophageal reflux was found in four more (8.7%) patients. CONCLUSIONS: This study indicates the possible role of weakly acid extraesophageal reflux episodes in some patients with globus pharyngeus. Other studies on this issue, including the use of biological markers such as signs of inflammation, are warranted. |
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Authors:
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Karol Zeleník; Petr Matoušek; Ondřej Urban; Pavel Schwarz; Ivo Stárek; Pavel Komínek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Laryngoscope Volume: 120 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 2160-4 Citation Subset: IM |
Affiliation:
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Department of Otorinolaryngology, University Hospital, Ostrava, Czech Republic. karol.zelenik@fno.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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administration & dosage* Adult Age Factors Body Mass Index Cohort Studies Female Follow-Up Studies Gastric Acidity Determination Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Monitoring, Physiologic / methods Prospective Studies Regurgitation, Gastric / diagnosis*, drug therapy* Risk Assessment Severity of Illness Index Sex Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 103577-45-3/lansoprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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