| Globus pallidus internal segment. | |
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MedLine Citation:
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PMID: 17499112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The internal segment of the globus pallidus (GP(i)) gathers many bits of information including movement-related activity from the striatum, external segment of the globus pallidus (GP(e)), and subthalamic nucleus (STN), and integrates them. The GP(i) receives rich GABAergic inputs from the striatum and GP(e), and gamma-aminobutyric acid (GABA) receptors are distributed in the GP(i) in a specific manner. Thus, inputs from the striatum and GP(e) may control GP(i) activity in a different way. The GP(i) finally conveys processed information outside the basal ganglia. Changes in GABAergic neurotransmission have been reported in movement disorders and suggested to play an important role in the pathophysiology of the symptoms. |
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Authors:
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Atsushi Nambu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in brain research Volume: 160 ISSN: 0079-6123 ISO Abbreviation: Prog. Brain Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376441 Medline TA: Prog Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-50 Citation Subset: IM |
Affiliation:
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Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo-naka, Myodaiji, Okazaki 444-8585, Japan. nambu@nips.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals GABA Plasma Membrane Transport Proteins / metabolism Globus Pallidus / anatomy & histology, physiology* Humans Movement / physiology Neural Inhibition / physiology Neural Pathways / anatomy & histology, physiology* Receptors, GABA / physiology* Synaptic Transmission / physiology gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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0/GABA Plasma Membrane Transport Proteins; 0/Receptors, GABA; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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