Document Detail

Global versus factor-related impression of severity in Parkinson's disease: a new clinimetric index (CISI-PD).
MedLine Citation:
PMID:  16161158     Owner:  NLM     Status:  MEDLINE    
In Parkinson's disease (PD), the Clinical Global Impression of Severity (CGIS) is often used as an additional outcome in clinical trials. It is hypothesized that this measure summarizes clinical assessment and is mainly influenced by the rating of four domains, namely, motor signs, disability, motor complications, and cognitive impairment. Ratings of these four factors were combined to form a new Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD). A sample of 150 PD patients was evaluated using the following scales: Hoehn and Yahr staging, Schwab and England scale, Unified Parkinson's Disease Rating Scale, Scales for Outcomes in Parkinson's Disease-Motor Scale, CGIS, and CISI-PD. The results show that the CGIS is closely related to the above-mentioned measures (r=0.49-0.89). CISI-PD correlation with these scales was very similar (r=0.55-0.91), to the extent that the difference between corresponding coefficients was systematically less than 0.10. A multiple regression model showed that 92% of the CIGS variance was explained by the four CISI-PD items. Finally, the CISI-PD displayed adequate psychometric properties, with satisfactory internal consistency (alpha=0.90) and convergent (r>0.75) and known-groups validity. The CISI-PD is a valid and reliable measure that expands the information obtained via the CGIS.
Pablo Martínez-Martín; M João Forjaz; Esther Cubo; Belén Frades; Jesús de Pedro Cuesta;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  21     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-16     Completed Date:  2006-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-14     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 Movement Disorder Society.
Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Cognition Disorders / classification,  diagnosis
Cross-Sectional Studies
Disability Evaluation*
Linear Models
Middle Aged
Neurologic Examination / statistics & numerical data*
Outcome Assessment (Health Care) / statistics & numerical data*
Parkinson Disease / classification,  diagnosis*
Reproducibility of Results

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