| Global policies and practices for managing persons exposed to multidrug-resistant tuberculosis. | |
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MedLine Citation:
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PMID: 20132616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SETTING: In the 1960s, treatment for latent tuberculosis infection (LTBI) with isoniazid proved to be so effective, safe, and inexpensive that research into alternative treatments virtually ceased. Now that multidrug-resistant tuberculosis (MDR-TB) is widespread, no data are available to guide the management of persons exposed to MDR-TB (contacts). METHODS: We surveyed National TB Program directors and MDR-TB program managers about current practices for managing MDR-TB contacts in countries with an MDR-TB prevalence of >2% in new patients and those with programs for managing MDR-TB. RESULTS: Of 35 countries that met the survey criteria, 25 (71%) responded; 24 of these (96%) have a guideline for managing TB contacts. Of these, 19 (76%) usually or always evaluated contacts and treated LTBI. In contrast, 10 (40%) countries reported having a guideline for managing MDR-TB contacts, 11 (44%) usually or always evaluated MDR-TB contacts, and 9 (36%) treated LTBI. Only two (8%) used a regimen that has activity against MDR-TB. Lack of evidence or guidelines was the main reason for not treating MDR-TB contacts. CONCLUSIONS: Management of MDR-TB contacts is inconsistent and ineffective due to lack of evidence-based guidelines. There is an urgent need to generate evidence to guide policy. |
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Authors:
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K P Cain; L J Nelson; J P Cegielski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 14 ISSN: 1815-7920 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
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Languages: eng Pagination: 269-74 Citation Subset: IM |
Affiliation:
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Division of Tuberculosis Elimination, and Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. kcain@cdc.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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pharmacology,
therapeutic use* Contact Tracing Data Collection Evidence-Based Medicine / methods Humans National Health Programs / statistics & numerical data Pilot Projects Practice Guidelines as Topic* Tuberculosis, Multidrug-Resistant / epidemiology, prevention & control* World Health |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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