Document Detail

Global left ventricular systolic function based on the sum of regional myocardial velocities during exercise echocardiography.
MedLine Citation:
PMID:  17555926     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to assess the relationship between global Doppler myocardial imaging (DMI) and left ventricular (LV) ejection fraction (LVEF) at both rest and exercise. BACKGROUND: We have previously demonstrated that global DMI correlates with LVEF at rest with low variability. METHODS: LVEF by 2-dimensional echocardiography, systolic global tissue Doppler velocity (s-TDV), strain (S) rate (SR), and S were assessed in 122 patients. LVEF was measured at rest and at peak exercise, whereas DMI was performed at rest and immediately postexercise. The region of interest by color DMI was set to enclose the external myocardial border when the LV achieved its maximal dimension. The means of the DMI assessments in the 4- and 2-chamber apical views at rest and postexercise were measured to correlate with LVEF. RESULTS: Significant correlations were found between the LVEF and global s-TDV, SR, and S either at rest (r = 0.32, r = 0.50, and r = 0.33, all P < .001) or at exercise (r = 0.47, r = 0.63, and r = 0.40, all P < .001). The best differentiation of an abnormal from a normal LVEF (>or=50%) at rest was provided by s-TDV less than 1.8 cm/s (sensitivity 63%, specificity 78%, area under the curve [AUC] 0.76, confidence interval [CI] 0.63-0.90), SR greater than -0.50/s (sensitivity 90%, specificity 76%, AUC 0.86, CI 0.76-0.97), and S greater than -9% (sensitivity 83%, specificity 75%, AUC 0.81, CI 0.70-0.91); whereas at exercise it was provided by s-TDV less than 3.5 cm/s (sensitivity 75%, specificity 74%, AUC 0.79, CI 0.69-0.89), SR greater than -0.80/s (sensitivity 83%, specificity 81%, AUC 0.91, CI 0.86-0.96), and S greater than -11% (sensitivity 67%, specificity 69%, AUC 0.74, CI 0.63-0.85). CONCLUSIONS: Global DMI is a valuable tool to assess global LV function during exercise.
Jesús Peteiro; Pablo Piñon; Alberto Bouzas; Diego Perez; Alfonso Castro-Beiras
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-06
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  20     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-04     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-73     Citation Subset:  IM    
Unit of Echocardiography and Department of Cardiology, Juan Canalejo Hospital, A Coruña, Spain. <>
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MeSH Terms
Echocardiography, Doppler, Color / methods*
Exercise Test*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Myocardial Infarction / complications,  ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume*
Ventricular Dysfunction, Left / etiology,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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