| Global cerebral hypoperfusion in preclinical stage of idiopathic normal pressure hydrocephalus. | |
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MedLine Citation:
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PMID: 20864126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with idiopathic normal pressure hydrocephalus (iNPH), ventriculomegaly and narrowed subarachnoid spaces at the high convexity appear in magnetic resonance (MR) images before the occurrence of objective symptoms. In addition, quantitative regional cerebral blood flow (rCBF) has been reported to be reduced in iNPH patients with objective symptoms. To determine whether reduced rCBF is responsible for the appearance of symptoms, we compared rCBF in patients with suspected iNPH with no objective triad symptoms (NOS), iNPH patients with apparent objective triad symptoms (AOS) and normal control subjects (NC). Regional CBF was quantified in 35 Regions-of-interest (ROIs) by 123I-IMP single photon emission computed tomography (SPECT) using the autoradiography (ARG) method. Multiple comparisons showed that, in all brain regions examined except for in the frontal white matter, rCBF in the NOS group was significantly lower than that in the NC group, but in all brain regions, not significantly different from that of the AOS group. These results suggest that factors other than rCBF in the resting state are responsible for the occurrence of objective symptoms of iNPH. |
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Authors:
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Masahiko Takaya; Hiroaki Kazui; Hiromasa Tokunaga; Tetsuhiko Yoshida; Yumiko Kito; Tamiki Wada; Keiko Nomura; Eku Shimosegawa; Jun Hatazawa; Masatoshi Takeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-22 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 298 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 35-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry, Osaka University Graduate School of Medicine, National Hospital Organization Osaka National Hospital, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Autoradiography Cerebrovascular Disorders / etiology*, physiopathology*, radionuclide imaging Cognition Disorders / etiology, psychology Disease Progression Female Gait Disorders, Neurologic / etiology, psychology Humans Hydrocephalus, Normal Pressure / complications*, physiopathology*, radionuclide imaging Iofetamine / diagnostic use Magnetic Resonance Angiography Magnetic Resonance Imaging Male Middle Aged Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 95896-48-3/Iofetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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