Document Detail

Global cell sorting is mediated by local cell-cell interactions in the C. elegans embryo.
MedLine Citation:
PMID:  16626685     Owner:  NLM     Status:  MEDLINE    
The Caenorhabditis elegans embryo achieves pattern formation by sorting cells into coherent regions before morphogenesis is initiated. The sorting of cells is coupled to their fate. Cells move extensively relative to each other to reach their correct position in the body plan. Analyzing the mechanism of cell sorting in in vitro culture experiments using 4D microscopy, we show that all AB-derived cells sort only according to their local neighbors, and that all cells are able to communicate with each other. The directions of cell movement do not depend on a cellular polarity but only on local cell-cell interactions; in experimental situations, this allows even the reversal of the polarity of whole regions of the embryo. The work defines a new mechanism of pattern formation we call "cell focusing".
Marcus Bischoff; Ralf Schnabel
Related Documents :
20020425 - Generation of histocompatible androgenetic embryonic stem cells using spermatogenic cells.
1648305 - Effects of early partial decapitation on the ontogenic development of chicken lymphoid ...
21042655 - Stress tolerance and transcriptional response in mouse embryos treated with high hydros...
9367635 - T-complex-associated embryonic surface antigen homologous to mlamp-1. i. biochemical an...
22729825 - Deciphering the route of ralstonia solanacearum colonization in arabidopsis thaliana ro...
3138155 - Arachidonic acid metabolism in respiratory epithelial cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-13
Journal Detail:
Title:  Developmental biology     Volume:  294     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-44     Citation Subset:  IM    
Technische Universität Braunschweig Carolo Wilhelmina, Institut für Genetik, Spielmannstr. 7, D-38106 Braunschweig, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Patterning*
Caenorhabditis elegans / cytology*,  embryology*,  physiology
Cell Communication / physiology
Cell Lineage
Cell Movement / physiology*
Embryo, Nonmammalian / anatomy & histology,  physiology
Models, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Global cell sorting in the C. elegans embryo defines a new mechanism for pattern formation.
Next Document:  Retinoic acid induces neurite outgrowth and growth cone turning in invertebrate neurons.