Document Detail


Global cell sorting is mediated by local cell-cell interactions in the C. elegans embryo.
MedLine Citation:
PMID:  16626685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Caenorhabditis elegans embryo achieves pattern formation by sorting cells into coherent regions before morphogenesis is initiated. The sorting of cells is coupled to their fate. Cells move extensively relative to each other to reach their correct position in the body plan. Analyzing the mechanism of cell sorting in in vitro culture experiments using 4D microscopy, we show that all AB-derived cells sort only according to their local neighbors, and that all cells are able to communicate with each other. The directions of cell movement do not depend on a cellular polarity but only on local cell-cell interactions; in experimental situations, this allows even the reversal of the polarity of whole regions of the embryo. The work defines a new mechanism of pattern formation we call "cell focusing".
Authors:
Marcus Bischoff; Ralf Schnabel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-13
Journal Detail:
Title:  Developmental biology     Volume:  294     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-44     Citation Subset:  IM    
Affiliation:
Technische Universität Braunschweig Carolo Wilhelmina, Institut für Genetik, Spielmannstr. 7, D-38106 Braunschweig, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning*
Caenorhabditis elegans / cytology*,  embryology*,  physiology
Cell Communication / physiology
Cell Lineage
Cell Movement / physiology*
Embryo, Nonmammalian / anatomy & histology,  physiology
Models, Biological
Morphogenesis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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